50656-39-8Relevant academic research and scientific papers
Enantioselective total synthesis of aspidophytine
Sumi, Shinjiro,Matsumoto, Koji,Tokuyama, Hidetoshi,Fukuyama, Tohru
, p. 1891 - 1893 (2003)
(Matrix presented) An enantioselective total synthesis of aspidophytine is described. The indole fragment bearing a cis-alkene substituent was efficiently prepared through radical cyclization of a 2-alkenylphenylisocyanide followed by Sonogashira coupling of the generated 2-iodoindole derivative with a functionalized acetylene unit. After formation of the 11-membered cyclic amine, the aspidosperma skeleton and lactone ring were constructed to complete the total synthesis.
