5066-50-2

Upstream product

• 2280-44-6 D-Glucose 
• 4245-37-8 vinyl methacrylate 
• 492-61-5 β-D-glucose 
• 760-93-0 methacryloyl anhydride 
• 920-46-7 Methacryloyl chloride 
• 2715-36-8 6-O-methacryloyl-1,2:3,4-di-O-isopropylidene-D-galactopyranose 
• 10257-28-0 D-Galactose 
• 7322-31-8 β-D-mannose 
• 4064-06-6 1,2:3,4-di-O-isopropylidene-α-D-galactopyranose 

Relevant academic research and scientific papers

Gambogic acid-galactose-HPMA (N-(2-hydroxypropyl)methacrylamide) high-molecular copolymer, and preparation method and application thereof

The invention discloses a gambogic acid-galactose-HPMA (N-(2-hydroxypropyl)methacrylamide) high-molecular copolymer. The structural formula is shown as (I) in the specification. In the formula, x=5-10 mol%, y=5-10 mol%, z=80-90 mol%, Mn=2.2*10, and Mw/Mn=1.45. A preparation method comprises the following steps: preparing a galactose derivative C by taking D-galactose as a preparation raw material; reacting gambogic acid oxalamide and methylacryloyl to prepare a gambogic acid derivative D; and finally, performing condensation on the galactose derivative C, the gambogic acid derivative D and HPMA to obtain the gambogic acid-galactose-HPMA high-molecular copolymer. After being used in a drug for treating a neoplastic disease, the copolymer has a targeted intelligent drug release functional and achieves a favorable inhibition effect for liver cancer, lung cancer and colon cancer.

METHODS FOR MAKING BIOCOMPATIBLE POLYMERIZABLE ACRYLATE PRODUCTS

Sugar-acrylic monomers are synthesized to have a carbohydrate moiety linked to an acrylate group. The sugar-acrylic monomers may be polymerized to form polymers, adhesives, hydrogels, and the like. The sugar-acrylic monomers and polymers may be used in tissue engineering, adhesives and sealers, wound healing, and the like.

Intracellular protein delivery by glucose-coated polymeric beads

Glucose-coated polymeric beads have been prepared and applied to delivery of a model protein (enhanced green fluorescent protein) into mouse embryonic stem cells as well as Hela cells.

Synthesis of water-soluble polymeric prodrugs possessing 4-methylcatechol derivatives by mechanochemical solid-state copolymerization and nature of drug release.

In this study we synthesized the water-soluble polymeric prodrugs possessing a 4-methylcatechol (4MC) derivative as a side chain by mechanochemical solid-state copolymerization. 1-benzoyl-4-methylcatechol (Bz4MC) was selected as a model compound of 4MC, and its methacryloyl derivative (1) was synthesized. 6-O-methacryloyl-D-galactose (2) was also prepared as a water-soluble monomer. The mechanochemical solid-state copolymerization of 1 and 2 was carried out to obtain the water-soluble polymeric prodrug possessing the Bz4MC as a side chain. The mechanochemical copolymerization of 1 and 2 proceeded to completion, and the polymeric prodrug produced possessed a narrow molecular weight distribution. Three kinds of polymeric prodrugs, whose compositions were different from one another, were hydrolyzed in vitro. The hydrolysis of these polymeric prodrugs proceeded to completion. The rate constants of hydrolysis decreased with increasing the mole fraction of 1 in polymeric prodrug. It was suggested that the rate constant of hydrolysis could be controlled by the composition, the mole fraction of 1 in the polymeric prodrug.

Differential activities of a lipase and a protease toward straight- and branched-chain acyl donors in transesterification to carbohydrates in an organic medium

Keywords: Lipases; Proteases; Acylation; Selective

Hydrophilic Reactive Polymer Gels, Part I: Synthesis and Polymerisation of Glucose and Sucrose Methacrylates

The synthesis of new hydrophilic polymer carriers on the basis of glucose and sucrose methacrylates is described.The monomer mixtures were prepared by reaction of glucose or sucrose with methacrylic anhydride or methacryloyl chloride in pyridine and by tr