5066-59-1

Upstream product

• 1878-68-8 2-(4-bromophenyl)-acetic acid 

Downstream Products

• 101279-28-1 2-chloro-benzaldehyde [4-(4-bromo-phenyl)-5-oxo-thiazolidin-2-ylidene]-hydrazone 
• 109251-46-9 4-methoxy-benzaldehyde [4-(4-bromo-phenyl)-5-oxo-thiazolidin-2-ylidene]-hydrazone 
• 101422-78-0 benzaldehyde [4-(4-bromo-phenyl)-5-oxo-thiazolidin-2-ylidene]-hydrazone 
• 92872-91-8 5-(4-bromo-phenyl)-2-(4-methyl-anilino)-thiazol-4-one 
• 97214-14-7 5-(4-bromo-phenyl)-2-(3-chloro-anilino)-thiazol-4-one 
• 93945-28-9 5-(4-bromo-phenyl)-2-(2,4-dichloro-anilino)-thiazol-4-one 
• 101422-79-1 2-hydroxy-benzaldehyde [4-(4-bromo-phenyl)-5-oxo-thiazolidin-2-ylidene]-hydrazone 
• 92439-56-0 2-anilino-5-(4-bromo-phenyl)-thiazol-4-one 
• 251366-61-7 α-bromo-(4-bromophenyl)acetamide 
• 251366-32-2 2-bromo-2-(p-fluorophenyl)acetamide 
• 1233941-59-7 5-(4-bromophenyl)-2-(pyridin-2-yl)-1,3-thiazol-4-ol 
• 1590450-44-4 N-benzoyl-O-[α-bromo-α-(p-bromophenyl)acetyl]-L-threonine isopropyl ester 
• 1590450-48-8 N-benzoyl-O-[α-bromo-α-(p-bromophenyl)acetyl]-L-threonine isopropyl ester 
• 1590450-52-4 N-benzoyl-O-[α-phenylthio-α-(p-bromophenyl)acetyl]-L-threonine isopropyl ester 

Relevant academic research and scientific papers

Copper-catalyzed synthesis of azaspirocyclohexadienones from ∝-azido- N -arylamides under an oxygen atmosphere

A copper-catalyzed reaction of ∝-azido-N-arylamides was found to proceed under an oxygen atmosphere to afford azaspirocyclohexadienones. The present transformation is carried out by a sequence of denitrogenative formation of iminyl copper species from ∝-azido-N-arylamides and their imino-cupration with an intramolecular benzene ring on the amido nitrogen followed by consecutive formation of C-O bonds. The preliminary investigation revealed that molecular oxygen is a prerequisite for achieving the present catalytic cyclization and that one of the oxygen atoms of O2 was found to be incorporated into the cyclohexadienone moiety.

Anti-viral compounds

The present invention relates to compounds of Formula (I) below, which inhibit the growth of picornaviruses, Hepatitus viruses, enteroviruses, cardioviruses, polioviruses, coxsackieviruses of the A and B groups, echo virus and Mengo virus. wherein: A is phenyl, pyridyl, substituted phenyl, substituted pyridyl, or benzyl; R is hydrogen, COR4, or COCF3; X is N—OH, O, or CHR1; R1is hydrogen, halo, CN, C1-C4alkyl, —C≡CH, CO(C1-C4alkyl), CO2(C1-C4alkyl), or CONR2R3; R2and R3are independently hydrogen or C1-C4alkyl; A′ is hydrogen, halo, C1-C6alkyl, benzyl, naphthyl, thienyl, furyl, pyridyl, pyrollyl, COR4, S(O)nR4, or a group of the formula R4is C1-C6alkyl, phenyl, or substituted phenyl; n is 0, 1, or 2; R5is independently at each occurrence hydrogen or halo; m is 1, 2, 3, or 4; and R6is hydrogen, halo, CF3, OH, CO2H, NH2, NO2, CONHOCH3, C1-C4alkyl, or CO2(C1-C4alkyl), C1-C4alkoxy; or a pharmaceutically acceptable salt thereof.