50666-68-7

Basic information

• Product Name: 1-Chloro-3-isopropylamino-2-propanol
• Synonyms: 1-Chloro-3-isopropylamino-2-propanol;2-Propanol, 1-chloro-3-[(1-methylethyl)amino]-
• CAS NO: 50666-68-7
• Molecular Formula: C₆H₁₄ClNO
• Molecular Weight: 151.63
• Mol File: 50666-68-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 244.0±25.0 °C(Predicted)
• Appearance: /
• Density: 1.038±0.06 g/cm3(Predicted)
• PKA: 13?+-.0.20(Predicted)
• CAS DataBase Reference: 1-Chloro-3-isopropylamino-2-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Chloro-3-isopropylamino-2-propanol(50666-68-7)
• EPA Substance Registry System: 1-Chloro-3-isopropylamino-2-propanol(50666-68-7)

Safety Data

• Hazardous Substances Data: 50666-68-7(Hazardous Substances Data)

Usage

General Description

1-Chloro-3-isopropylamino-2-propanol, also known as chloroprocaine, is a local anesthetic and a potent sodium channel blocker. It is commonly used for spinal and epidural anesthesia during childbirth and for various surgical procedures. Chloroprocaine works by preventing the transmission of pain signals from nerve endings to the brain, leading to temporary numbness in the affected areas. Its rapid onset and short duration of action make it a preferred choice for procedures that require quick anesthesia and a fast recovery time. However, it can also cause side effects such as hypotension, headache, and dizziness, and should be used with caution in individuals with certain medical conditions. Overall, chloroprocaine is an important and widely used chemical in the field of anesthesiology.

Upstream product

• 75-31-0 isopropylamine 
• 106-89-8 epichlorohydrin 

Downstream Products

• 76226-42-1 1-[4-(4-Chloro-phenyl)-5-pyridin-4-yl-4H-[1,2,4]triazol-3-ylsulfanyl]-3-isopropylamino-propan-2-ol; hydrochloride 
• 56442-83-2 1-(Diphenylmethylen)iminoxy-3-isopropylamino-2-propanol 
• 83277-30-9 5-hydroxymethyl-3-isopropyloxazolidin-2-one 
• 170489-91-5 R,S-2-(E)-(4-Chlorophenyl-methylene)-1-(E)-[3-(1-methylethylamino)-2-hydroxy-propoxyimino]-cyclohexane 
• 35736-21-1 1-[(p-N',N'-dimethyl-ureido)-phenoxy]-2-hydroxy-3-isopropylamino-propane 
• 13156-06-4 1-isopropyl-azetidin-3-ol 
• 33947-97-6 4-(2-Hydroxy-3-isopropylamino-propoxy)-benzoic acid methyl ester 
• 38649-81-9 1-Cycloheptyl-3-[4-(2-hydroxy-3-isopropylamino-propoxy)-phenyl]-urea 
• 38649-79-5 1-Cyclopentyl-3-[4-(2-hydroxy-3-isopropylamino-propoxy)-phenyl]-urea 
• 38649-80-8 1-((E)-But-2-enyl)-3-[4-(2-hydroxy-3-isopropylamino-propoxy)-phenyl]-urea 
• 38649-78-4 1-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-3-(3-methyl-butyl)-urea 
• 38649-77-3 1-sec-Butyl-3-[4-(2-hydroxy-3-isopropylamino-propoxy)-phenyl]-urea 
• 38649-82-0 1-Cyclopropyl-3-[4-(2-hydroxy-3-isopropylamino-propoxy)-phenyl]-urea 
• 38649-75-1 1-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-3-isopropyl-urea 

Relevant articles and documents

Switchable synthesis of cyclic carbamates by carbon dioxide fixation at atmospheric pressure

The base-promoted switchable synthesis of five- and six-membered cyclic carbamates using atmospheric pressure carbon dioxide as the C1 source was developed. The chemoselectivity of products was simply controlled by changing bases and solvents. The reaction proceeds effectively under mild conditions, affording valuable cyclic carbamates. Experimental results and DFT studies revealed the reaction mechanism.

Preparation of 3-Azetidinols with Non-Bulky 1-Alkyl Substituents

Cyclization of either the tetrahydropyranyl or trimethylsilyl ether of 1-(alkylamino)-3-chloro-2-propanols 1 followed by cleavage of the azetidinyl ether provides a general method for the preparation of 1-alkyl-3-azetidinols.Unhindered amines provide a more facile preparation of derivatives of 1, or its ethers, than do hindered amines, while hindered derivatives of 1 undergo more facile ring closure.

Beta-adrenergic blocking agents. 9. Absolute configuration of propranolol and of a number of related aryloxypropanolamines and arylethanolamines.

-