50685-05-7Relevant academic research and scientific papers
Impact of Dehydroamino Acids on the Structure and Stability of Incipient 310-Helical Peptides
Joaquin, Daniel,Lee, Michael A.,Kastner, David W.,Singh, Jatinder,Morrill, Shardon T.,Damstedt, Gracie,Castle, Steven L.
, p. 1601 - 1613 (2019/12/02)
A comparative study of the impact of small, medium-sized, and bulky α,β-dehydroamino acids (AAs) on the structure and stability of Balaram's incipient 310-helical peptide (1) is reported. Replacement of the N-terminal Aib residue of 1 with a AA
A new and convenient method for the synthesis of dehydroamino acids starting from ethyl N-Boc- and N-Z-α-tosylglycinates and various nitro compounds
Nagano, Tanemasa,Kinoshita, Hideki
, p. 1605 - 1613 (2007/10/03)
Ethyl N-Boc- and N-Z-α-tosylglycinates, which were readily available from t-butyl or benzyl carbamate, ethyl glyoxylate, and sodium p- toluenesulfinate in formic acid, were reacted with a variety of nitro compounds in the presence of a base to afford the corresponding α,β- didehydroamino acid derivatives in good yields. Eventually, it was found that the (Z)-isomer was predominantly formed in the present method.
