5069-64-7Relevant articles and documents
Hypoxia-driven elimination of thiopurines from their nitrobenzyl prodrugs
Thomson, Peter,Naylor, Matthew A.,Stratford, Michael R.L.,Lewis, Gemma,Hill, Sally,Patel, Kantilal B.,Wardman, Peter,Davis, Peter D.
, p. 4320 - 4322 (2007)
A novel bioreductive prodrug of 6-thioguanine, 2-amino-6-[2-(4-nitrophenyl)prop-2-ylsulfanyl]-9H-purine, containing a gem-dimethyl thioether linkage, was synthesised and compared with its unsubstituted analogue. In A549 whole cell experiments hypoxia sele