50707-36-3Relevant articles and documents
A new and efficient palladium-catalyzed synthesis of a 2,3,4,5- tetrahydro-1H-2,4-benzodiazepine-1,3-dione derivative
Bocelli, Gabriele,Catellani, Marta,Cugini, Federica,Ferraccioli, Raffaella
, p. 2623 - 2624 (2007/10/03)
The palladium-catalyzed intramolecular cyclization of 1-butyl-1(o- iodobenzyl)-3-phenylurea 1 at 80°C in the presence of carbon monoxide at atmospheric pressure gives the corresponding 2,3,4,5-tetrahydro-1H-2,4- benzodiazepine-1,3-dione derivative 2 in 91% yield. Yield and selectivity are strongly affected by the solvent.
