50718-91-7Relevant academic research and scientific papers
Synthesis of carbon-14 labelled gemifloxacin
Shin, Hyun Il,Rim, Jong Gill,Lee, Ki Seung,Kim, Young Seok,Nam, Do Hyun,Shin, Hyun Ik,Chang, Jay Hyok,Oh, Chang Young,Ham, Won Hun
, p. 779 - 786 (2007/10/03)
A new antibacterial agent gemifloxacin was labelled with carbon-14 for studies of pharmacokinetics and metabolism, the label was located in position 3 of the quinolone ring system. The overall radiochemical yield of the 14-step synthesis, starting from [2-14C]sodium acetate was 16.6%, and the radiochemical purity 97.5%.
Carbon kinetic isotope effects and transition structures in the rearrangements of allyl vinyl ethers. 2-(trimethylsiloxy)- and 2-(methoxycarbonyl)-3-oxa-1,5-hexadiene
Kupczyk-Subotkowska, Lidia,Saunders Jr., William H.,Shine, Henry J.,Subotkowski, Witold
, p. 7088 - 7093 (2007/10/02)
14C KIE (kinetic isotope effects) were measured for the C-1, C-2, C-4, and C-6 positions in the rearrangement of 2-(trimethylsiloxy)- (1a) and 2-(methoxycarbonyl)-3-oxa-1,5-hexadiene (1b). The data, along with earlier C-4 and C-6 deuterium KIE, were fitted to Bebovib modeling calculations. The calculations show that in the transition structure (TS) for 1a 70-80% bond breaking and 20% of bond making occurs, whereas in the TS of 1b both bond breaking and bond making amount to 30-40%. Results for 1a and 1b are compared with earlier results for the parent compound, allyl vinyl ether.
