507231-36-9Relevant academic research and scientific papers
Synthesis of (Z)-α-chloro-α,β-unsaturated esters with complete stereoselectivity promoted by samarium diiodide
Concellón, José M.,Huerta, Mónica,Llavona, Ricardo
, p. 4665 - 4667 (2007/10/03)
Stereoselective β-elimination in α,α-dichloro-β- hydroxyesters 2 was achieved by using samarium diiodide, yielding (Z)-α-chloro-α,β-unsaturated esters 1. The starting compounds 2 were easily prepared by reaction of the lithium enolate of ethyl dichloroacetate with different aldehydes at -78°C. A mechanism to explain this process is proposed.
Synthesis of dihalohydrins and tri- and tetra-substituted olefins
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Page 7, (2008/06/13)
A novel synthesis reaction for highly stereospecific tri- and tetra-substituted olefins is described. A single stereoisomer of stable α-halo-α,β-ester is produced in high yield by the reaction of aldehyde or ketone with a trihalogenated compound such as t
(Z)-α-haloacrylates: An exceptionally stereoselective preparation via Cr(II)-mediated olefination of aldehydes with trihaloacetates
Barma,Kundu, Abhijit,Zhang, Hongming,Mioskowski, Charles,Falck
, p. 3218 - 3219 (2007/10/03)
(Z)-α-Fluoro-, (Z)-α-chloro-, and (Z)-α-bromoacrylates were obtained with unprecedented yield and stereocontrol (>99%) via addition of the corresponding commercial trihaloacetates to aldehydes at room temperature using stoichiometric Cr(II) salts or catal
Inhibition of telomerase by BIBR 1532 and related analogues
Barma,Elayadi, Anissa,Falck,Corey, David R.
, p. 1333 - 1336 (2007/10/03)
BIBR 1532 has been reported to be a potent, small molecule inhibitor of human telomerase, suggesting it as a lead for the development of anti-telomerase therapy. We confirm the ability of BIBR 1532 to inhibit telomerase and report the discovery of an equa
