507233-34-3Relevant academic research and scientific papers
Simple highly modular acyclic amine-catalyzed direct enantioselective addition of ketones to nitro-olefins
Xu, Yongmei,Cordova, Armando
, p. 460 - 462 (2006)
Simple, highly modular primary amino acid derivatives catalyze the direct enantioselective addition of ketones to nitro-olefins with high stereocontrol and furnish the corresponding aldol products in high yield with up to >38 : 1 dr and up to 99% ee. The
Copper-Catalyzed Tertiary Alkylative Cyanation for the Synthesis of Cyanated Peptide Building Blocks
Miwa, Naoki,Tanaka, Chihiro,Ishida, Syo,Hirata, Goki,Song, Jizhou,Torigoe, Takeru,Kuninobu, Yoichiro,Nishikata, Takashi
supporting information, p. 1692 - 1697 (2020/02/04)
In this paper, we report efficient cyanation of various peptides containing the α-bromocarbonyl moiety using a Cu-catalyzed radical-based methodology employing zinc cyanide as the cyanide source. Mechanistic studies revealed that in situ formed CuCN was a key intermediate during the catalytic cycle. Our method could be useful for the synthesis of modified peptides containing quaternary carbons.
Constrained TRPV1 agonists synthesized via silver-mediated intramolecular azo-methine ylide cycloaddition of α-iminoamides
Painter, Thomas O.,Kaszas, Krisztian,Gross, Jacklyn,Douglas, Justin T.,Day, Victor W.,Iadarola, Michael J.,Santini, Conrad
, p. 963 - 968 (2014/02/14)
As part of an effort to identify agonists of TRPV1, a peripheral sensory nerve ion channel, high throughput screening of the NIH Small Molecule Repository (SMR) collection identified MLS002174161, a pentacyclic benzodiazepine. A synthesis effort was initi
