50729-62-9Relevant academic research and scientific papers
Site-Selective Thiolation of (Multi)halogenated Heteroarenes
Sandfort, Frederik,Knecht, Tobias,Pinkert, Tobias,Daniliuc, Constantin G.,Glorius, Frank
supporting information, p. 6913 - 6919 (2020/05/14)
A general and simple strategy for the site-selective thiolation of various pharmaceutically relevant electron-rich heteroarenes with thiols is reported. This mild and reliable photocatalytic protocol enables C-S coupling at the most electron-rich position of the (multi)halogenated substrates, complementing established methodologies. Experimental and computational studies suggest a radical chain mechanism with the key step being a homolytic aromatic substitution of the heteroaryl halide by an electrophilic thiyl radical, highlighting an underdeveloped reactivity mode.
SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES
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Page/Page column 14; 57-58, (2019/11/12)
The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3, R4, R5, R6 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.
THIAZOLE MODULATORS OF A3 ADENOSINE RECEPTORS
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Paragraph 0147, (2017/12/27)
Modulators of adenosin A3 receptors of formula (I) and procedure for preparing these compounds. Other objectives of the present invention are to provide pharmaceutical compositions comprising an effective amount of these compounds and the use o
