50738-83-5Relevant academic research and scientific papers
Novel class of DNA binding motifs based on bistetrahydrofuran and bisfuran skeleton with long alkyl chains
Sasaki,Shibata,Torigoe,Shibata,Maeda
, p. 551 - 558 (2001)
Small molecules with DNA-binding affinity within the minor groove have become of great interest. In this paper, new DNA binding molecules; diaminobistetrahydrofuran (bisTHF) and diamino-bisfuran are reported. The bisTHF ligand with RR configuration at the amino groups and C8 alkyl chains (RR8) stabilized GC-rich duplex. In contrast, bisfuran compounds stabilized AT-rich duplex. The binding affinity of RR8 with 12 mer duplex DNA was determined by isothermal titration calorimetry to be 3.3 × 108 M-1.
Synthesis of furan dimer-based polyamides with a high melting point
Miyagawa, Naoki,Suzuki, Toyoko,Okano, Kentaro,Matsumoto, Takuya,Nishino, Takashi,Mori, Atsunori
, p. 1516 - 1519 (2018)
Polyamide composed of furan dimer, which is prepared from biomass-derived organic molecule 2-furfural, is synthesized. The reaction of 2,2′-furan dimer 5,5′-dicarbonyl chloride with several 1,ω-diamines was carried out with a solution or interfacial polycondensation leading to the corresponding polyamide. Measurement of the melting point was performed resulting to exhibit a higher temperature compared with the related polyamide bearing a single furan ring composed of furan-2,5-dicarboxylic acid (FDCA). Thermal analyses (TG–DTA) also indicated higher temperatures of decomposition than those of FDCA-derived polyamide.
Method for preparing 5,5'-difurandicarboxylic acid
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Paragraph 0035-0100, (2020/02/14)
The invention belongs to the field of organic synthesis and catalysis, The invention discloses a method for preparing 5,5'-difurandicarboxylic acid. According to the method, 5,5'-difurandicarboxylic acid is obtained by stirring a reaction system containing 5-bromofuroic acid, water, an inorganic base, a supported catalyst and a reducing agent for reacting at a temperature of 60-90 DEG C for 10-80minutes. The 5-bromofuroic acid has a chemical structure represented by the following formula 1, and the 5,5'-difurandicarboxylic acid has a chemical structure represented by a following formula 2. According to the invention, 5-bromofuroic acid is used as a raw material, various reactants participating in construction of the reaction system, reaction conditions and the like are improved, and therefore, compared with the prior art, the method has the advantages of effectively solving the problems of low yield or harsh reaction conditions. Structural formula of the compound represented by the formula 1 and the compound represented by the formula 2 are as described in the specification.
