507476-70-2

Usage

Uses

Used in Pharmaceutical Industry:
5-Bromoquinoline-8-carbonitrile is used as a key intermediate for the synthesis of potential drug candidates aimed at treating a range of diseases, including cancer and infectious diseases. Its application is primarily due to its ability to contribute to the development of novel therapeutic agents with enhanced efficacy and selectivity.
Used in Research and Development:
In the realm of scientific research, 5-bromoquinoline-8-carbonitrile is utilized as a research chemical. It aids in the study of chemical reactions and organic synthesis processes, thereby facilitating the discovery and optimization of new chemical entities with potential pharmaceutical applications.
The diverse applications of 5-bromoquinoline-8-carbonitrile underscore its importance in both the development of new pharmaceuticals and the advancement of chemical research, making it a valuable asset in the field of medicinal chemistry.

Upstream product

• 885267-41-4 5-bromoquinoline-8-carboaldehyde 
• 557-21-1 zinc(II) cyanide 
• 573758-03-9 5-amino-quinoline-8-carbonitrile 

Downstream Products

• 1445782-00-2 5-(((3S,4R)-4-(3-(trifluoromethoxy)phenyl)pyrrolidin-3-yl)amino)quinoline-8-carboxamide 

Relevant academic research and scientific papers

NUCLEIC ACID-BINDING PHOTOPROBES AND USES THEREOF

The present invention relates to photoactivatable compounds and methods of use thereof for determining binding site and other structural information about RNA transcripts. The invention also provides methods of identifying RNA transcripts that bind compounds and are thus druggable, methods of screening drug candidates, and methods of determining drug binding sites and/or accessible or reactive sites on a target RNA.

COMPOUNDS AND METHODS FOR MODULATING RNA FUNCTION

The present invention provides compounds, compositions thereof, and methods of using the same.

POLYCYCLIC TLR7/8 ANTAGONISTS AND USE THEREOF IN THE TREATMENT OF IMMUNE DISORDERS

The present invention relates to compounds of Formula (I) and pharmaceutically acceptable compositions thereof, useful as toll-like receptor 7/8 (TLR7/8) antagonists. In Formula (I), Ring A is aryl or heteroaryl; Ring B is aryl or heteroary; and X is C(R4)2, O, NR4, S, S(R4), or S(R4)2.

COMPOUNDS AND METHODS OF TREATING RNA-MEDIATED DISEASES

The present invention provides compounds, compositions thereof, and methods of using the same.

CCR6 COMPOUNDS

Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6. Pharmaceutical compositions of the compounds of formula (I) are also provided. Further provided in the present disclosure

SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS

Embodiments of the disclosure relate to selectively substituted quinoline compounds of formula (I) that act as antagonists or inhibitors for Toll -like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic

SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS

Embodiments of the disclosure relate to selectively substituted quinoline compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.

PIPERAZINE DERIVATIVES AND THEIR USE AS MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION

The present invention provides piperazine derivatives and methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders.