507478-16-2Relevant academic research and scientific papers
Novel tetrahydrochinoline derived CETP inhibitors
Schmeck, Carsten,Gielen-Haertwig, Heike,Vakalopoulos, Alexandros,Bischoff, Hilmar,Li, Volkhart,Wirtz, Gabriele,Weber, Olaf
scheme or table, p. 1740 - 1743 (2010/07/03)
In the course of our efforts to identify orally active cholesteryl ester transfer protein (CETP) inhibitors, we have continued to explore tetrahydrochinoline derivatives. Based on BAY 19-4789 structural modifications led to the discovery of novel cycloalkyl substituted compounds. Thus, example 11b is a highly potent CETP inhibitor both in vitro and in vivo in transgenic mice with favourable pharmacokinetic properties for clinical development.
