507480-63-9

Basic information

• Product Name: C₅₇H₉₈O₁₂S₂Si₂
• Synonyms: C₅₇H₉₈O₁₂S₂Si₂
• CAS NO: 507480-63-9
• Molecular Weight: 1095.7
• Mol File: 507480-63-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₅₇H₉₈O₁₂S₂Si₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₅₇H₉₈O₁₂S₂Si₂(507480-63-9)
• EPA Substance Registry System: C₅₇H₉₈O₁₂S₂Si₂(507480-63-9)

Safety Data

• Hazardous Substances Data: 507480-63-9(Hazardous Substances Data)

Upstream product

• 247200-05-1 Toluene-4-sulfonic acid (E)-(1S,2R)-1-[(3R,4R)-7-benzyloxy-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-heptyl]-2-methoxymethoxy-dodec-3-enyl ester 
• 247200-06-2 Toluene-4-sulfonic acid (1S,2R)-1-[(3R,4R)-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-7-hydroxy-heptyl]-2-methoxymethoxy-dodecyl ester 
• 247200-07-3 Toluene-4-sulfonic acid (1S,2R)-1-[(3R,4R)-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-7-oxo-heptyl]-2-methoxymethoxy-dodecyl ester 
• 247200-04-0 (E)-(4R,5R,8S,9R)-1-Benzyloxy-4,5-bis-(tert-butyl-dimethyl-silanyloxy)-9-methoxymethoxy-nonadec-10-en-8-ol 
• 204572-66-7 (4R,5R)-8-Benzyloxy-4,5-bis-(tert-butyl-dimethyl-silanyloxy)-octanal 
• 98-59-9 p-toluenesulfonyl chloride 
• 507480-62-8 Toluene-4-sulfonic acid (E)-(1S,4R,5R,8S,9R)-4,5-bis-(tert-butyl-dimethyl-silanyloxy)-8-hydroxy-9-methoxymethoxy-1-((R)-1-methoxymethoxy-undecyl)-hexadec-10-en-15-ynyl ester 

Downstream Products

• 102989-24-2 (+)-asimicin 

Relevant articles and documents

A modular synthesis of annonaceous acetogenins

A synthesis of four Annonaceous acetogenins, asiminocin, asimicin, asimin, and bullanin, by a modular approach from seven fundamental subunits, A-G, is described. The approach employs a central core aldehyde segment, C, to which are appended an aliphatic terminus, A or B, a spacer subunit, D or E, and a butenolide terminus, F or G. Coupling of the A, B, D, and E segments to the core aldehyde unit is effected by highly diastereoselective additions of enantiopure allylic indium or tin reagents. The butenolide termini are attached to the ACD, BCE, or BCD intermediates by means of a Sonogashira coupling. The design of the core, spacer, and termini subunits is such that any of the C30, C10, or C4 natural acetogenins or stereoisomers thereof could be prepared. IC50 values for the four aforementioned acetogenins against H-116 human colon cancer cells were found to be in the 10-3 to 10-4 μM range. The IC90 activities were ca. 10-3 μM for asimicin and asimin but only 0.1-1 μM for bullanin and asiminocin.