507481-64-3

Upstream product

• 60168-64-1 1-phenyl-2-(2-propenyloxy)-1-ethanol 

Downstream Products

• 507481-66-5 7-(2-allyloxy-1-phenylethyl)-2-amino-6-chloropurine 
• 746647-93-8 1-[2-(allyloxy)-1-phenylethyl]-7-methyl-10-oxo-9,10-dihydropyrimido[1,2-a]purine 
• 341968-36-3 1-(2-allyloxy-1-phenyl-ethoxy)-2,2,6,6-tetramethyl-piperidin 
• 262842-88-6 3-(2-hydroxy-1-phenylethyl)adenine 
• 35285-58-6 9-(2-hydroxy-1-phenylethyl)adenine 
• 1041467-66-6 8-bromo-9-(2-allyloxy-1-phenylethyl)adenine 
• 1041467-64-4 8-bromo-3-(2-allyloxy-1-phenylethyl)adenine 
• 507481-72-3 7-[2-(allyloxy)-1-phenylethyl]-2-aminopurin-6-one 

Relevant academic research and scientific papers

Syntheses of 7-(2-hydroxy-1-phenylethyl)- and 7-(2-hydroxy-2-phenylethyl) guanine, DNA adducts derived from styrene 7,8-oxide

7-(2-Hydroxy-1-phenylethyl)- and 7-(2-hydroxy-2-phenylethyl)guanines are important DNA adducts which can be used as markers of exposure to styrene. Two synthetic routes leading to these compounds are presented using allyl-protected bromohydrins as synthetic equivalents of styrene oxide to alkylate 2-amino-6-chloropurine or 7-methyl-10-oxo-9,10-dihydropyrimido[1,2-a]purine as precursors to guanine. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.

Synthesis of 7-hydroxy(phenyl)ethylguanines by alkylation of 2-amino-6-chloropurine with allyl-protected bromohydrins

(Matrix presented) Protecting the hydroxyl group in both 2-bromo-2-phenylethanol and 2-bromo-1-phenylethanol enhanced the alkylation of 2-amino-6-chloropurine to give corresponding 7- and 9-alkylated products. Subsequent hydrolysis and deprotection led to