5076-24-4Relevant articles and documents
Prodrugs of GABA analogs, compositions and uses thereof
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Page/Page column 39, (2010/11/24)
The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using pharmaceutical compositions of prodrugs of GABA analogs for treating or preventing common diseases and/or disorders.
Synthesis and Thermal Stability of Silver Carboxylates: Crystal Structure of Silver Pivalate
Paramonov,Mychlo,Troyanov,Kuz'mina
, p. 1852 - 1856 (2008/10/08)
Silver(I) carboxylates Ag(RCOO) (R = i-Pr, n-Pr, t-Bu, i-Bu) are synthesized by reactions between AgNO3 and potassium carboxylates in aqueous solutions and characterized by elemental analysis and IR spectroscopy. The X-ray structure of Ag(t-BuCOO) is determined: space group P1 a = 5.810(3) ?, b = 13.646(5) ?, c = 16.700(5) ?, α = 107.56(3)°, β= 90.47(4)°, γ= 94.24(3)°, and Z= 4. The structure consists of polymeric chains formed by silver pivalate dimers, each linked with the two neighbors by two extra Ag-O bonds. The intradimer Ag-O bond lengths are 2.17 and 2.20 ?. In a nitrogen atmosphere at p= 1 atm, all of the Ag(RCOO) compounds decompose to Ag between 120 and 250°C. At a reduced pressure of 0.01 mmHg, they can be sublimed at 220 to 250°C. The thermal stability and volatility of Ag(RCOO) increases in the R order i-Pr n-Pr ~ t-Bu ~ i-Bu.