50772-82-2 Usage
Benzene derivative
A compound based on the benzene structure, with modifications to its hydrogen atoms through substitution or addition of functional groups.
Methoxy group
A functional group consisting of an oxygen atom and a methyl group (-OCH3) attached to the benzene ring, specifically at the 2nd carbon atom.
Methyl groups
Two alkyl groups (-CH3) attached to the benzene ring at the 4th and 5th carbon atoms, contributing to the structure's complexity.
Iodo group
A halogen atom (Iodine) attached to the 1st carbon atom of the benzene ring, which influences the compound's reactivity and properties.
Use in organic synthesis and pharmaceutical research
The compound serves as a starting material for synthesizing various biologically active molecules, making it valuable in the creation of new drugs and chemical compounds.
Hazardous nature
The chemical is considered hazardous due to its potential to cause harm to human health and the environment.
Irritation potential
Exposure to skin, eyes, or respiratory system may result in irritation, necessitating proper handling and protective measures.
Ingestion and inhalation hazards
Swallowing or inhaling the compound can be harmful, emphasizing the importance of proper storage and handling practices.
Proper storage and handling
The compound should be stored and used in a well-ventilated area and handled with appropriate personal protective equipment to minimize exposure and potential hazards.
Check Digit Verification of cas no
The CAS Registry Mumber 50772-82-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,0,7,7 and 2 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 50772-82:
(7*5)+(6*0)+(5*7)+(4*7)+(3*2)+(2*8)+(1*2)=122
122 % 10 = 2
So 50772-82-2 is a valid CAS Registry Number.
50772-82-2Relevant articles and documents
One-pot ortho-amination of aryl C-H bonds using consecutive iron and copper catalysis
Henry, Martyn C.,McGrory, Rochelle,Faggyas, Réka J.,Mostafa, Mohamed A. B.,Sutherland, Andrew
, p. 4629 - 4639 (2019/05/17)
A one-pot approach for ortho-coupling of arenes with non-actived N-nucleophiles has been developed using sequential iron and copper catalysis. Regioselective ortho-activation of anisoles, anilines and phenols was achieved through iron(iii) triflimide catalysed iodination, followed by a copper(i)-catalysed, ligand-assisted coupling reaction with N-heterocycle, amide and sulfonamide-based nucleophiles. The synthetic utility of this one-pot, two-step method for the direct amination of ortho-aryl C-H bonds was demonstrated with the late-stage functionalisation of 3,4-dihydroquinolin-2-ones. This allowed the preparation of a TRIM24 bromodomain inhibitor and a series of novel analogues.
