50776-26-6 Usage
Description
4-METHYL-3,4-DIHYDRO-2H-CYCLOPENTA[B]INDOL-1-ONE, commonly known as Sertraline, is a selective serotonin reuptake inhibitor (SSRI) that functions as an antidepressant medication. It operates by elevating the levels of serotonin, a neurotransmitter in the brain that is instrumental in mood regulation, emotional state, and behavior. Sertraline is widely recognized for its effectiveness in treating a range of mood and anxiety disorders.
Uses
Used in Pharmaceutical Industry:
4-METHYL-3,4-DIHYDRO-2H-CYCLOPENTA[B]INDOL-1-ONE is used as an antidepressant medication for the treatment of major depressive disorder, providing relief by modulating the levels of serotonin in the brain.
4-METHYL-3,4-DIHYDRO-2H-CYCLOPENTA[B]INDOL-1-ONE is also used as a treatment for obsessive-compulsive disorder, helping to alleviate the persistent, unwanted thoughts and repetitive behaviors characteristic of this condition.
In the treatment of panic disorder, 4-METHYL-3,4-DIHYDRO-2H-CYCLOPENTA[B]INDOL-1-ONE is utilized to reduce the frequency and intensity of sudden, overwhelming feelings of fear and anxiety.
For social anxiety disorder, 4-METHYL-3,4-DIHYDRO-2H-CYCLOPENTA[B]INDOL-1-ONE is employed to diminish the extreme fear of social situations, which can interfere with daily life and social interactions.
Additionally, 4-METHYL-3,4-DIHYDRO-2H-CYCLOPENTA[B]INDOL-1-ONE is used in post-traumatic stress disorder treatment, aiding in the management of symptoms that can arise after experiencing or witnessing a traumatic event.
4-METHYL-3,4-DIHYDRO-2H-CYCLOPENTA[B]INDOL-1-ONE is available in tablet and oral concentrate forms for easy administration and is typically taken once a day, with or without food. As with all medications, it is essential to take Sertraline under the guidance of a healthcare professional to manage potential side effects and ensure safe and effective treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 50776-26-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,0,7,7 and 6 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 50776-26:
(7*5)+(6*0)+(5*7)+(4*7)+(3*6)+(2*2)+(1*6)=126
126 % 10 = 6
So 50776-26-6 is a valid CAS Registry Number.
50776-26-6Relevant articles and documents
C-H Activation-Based Traceless Synthesis via Electrophilic Removal of a Directing Group. Rhodium(III)-Catalyzed Entry into Indoles from N-Nitroso and α-Diazo-β-keto Compounds
Wang, Jie,Wang, Mingyang,Chen, Kehao,Zha, Shanke,Song, Chao,Zhu, Jin
supporting information, p. 1178 - 1181 (2016/03/15)
A distinct C-H activation-based traceless synthetic protocol via electrophilic removal of a directing group is reported, complementing the currently exclusively used nucleophilic strategy. Rh(III)-catalyzed, N-nitroso-directed C-H activation allows the development of a traceless, atom- and step-economic, cascade approach for the synthesis of indole skeletons, starting from readily available N-nitroso and α-diazo-β-keto compounds. Importantly, the cyclization/denitrosation reaction represents a hitherto unobserved reactivity pattern for the N-nitroso group.
Synthesis of Cyclopenta[b]indol-1-ones and Carbazol-4-ones from N-(2-Halophenyl)-Substituted Enaminones by Intramolecular Heck Reaction
Sorensen, Ulrik S.,Pombo-Villar, Esteban
, p. 82 - 89 (2007/10/03)
An efficient synthetic route towards N-methylated or nonmethylated 3,4-dihydrocyclopent[b]indol-1(2H)-ones (3) and 1,2,3,9-tetrahydrocarbazol-4(4H)-one (10) was elaborated, based on Pd-catalyzed intramolecular Heck reaction. The chemoselectivity of the cyclization was studied in the case of the bi- and trifunctional substrates 12 and 17, respectively. In the latter case, depending on the catalyst, either the brominated indole 18 or the tetracyclic compound 19 were obtained by single and double Heck reaction, respectively.
