50776-26-6

Usage

Uses

Used in Pharmaceutical Industry:
4-METHYL-3,4-DIHYDRO-2H-CYCLOPENTA[B]INDOL-1-ONE is used as an antidepressant medication for the treatment of major depressive disorder, providing relief by modulating the levels of serotonin in the brain.
4-METHYL-3,4-DIHYDRO-2H-CYCLOPENTA[B]INDOL-1-ONE is also used as a treatment for obsessive-compulsive disorder, helping to alleviate the persistent, unwanted thoughts and repetitive behaviors characteristic of this condition.
In the treatment of panic disorder, 4-METHYL-3,4-DIHYDRO-2H-CYCLOPENTA[B]INDOL-1-ONE is utilized to reduce the frequency and intensity of sudden, overwhelming feelings of fear and anxiety.
For social anxiety disorder, 4-METHYL-3,4-DIHYDRO-2H-CYCLOPENTA[B]INDOL-1-ONE is employed to diminish the extreme fear of social situations, which can interfere with daily life and social interactions.
Additionally, 4-METHYL-3,4-DIHYDRO-2H-CYCLOPENTA[B]INDOL-1-ONE is used in post-traumatic stress disorder treatment, aiding in the management of symptoms that can arise after experiencing or witnessing a traumatic event.
4-METHYL-3,4-DIHYDRO-2H-CYCLOPENTA[B]INDOL-1-ONE is available in tablet and oral concentrate forms for easy administration and is typically taken once a day, with or without food. As with all medications, it is essential to take Sertraline under the guidance of a healthcare professional to manage potential side effects and ensure safe and effective treatment.

Upstream product

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• 874915-57-8 N,N-diethyl-3-(1H-indol-2-yl)-propionamide 
• 874915-04-5 N,N-diethyl-3-(1'-methyl-1H-indol-2'-yl)propanamide 
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Relevant academic research and scientific papers

C-H Activation-Based Traceless Synthesis via Electrophilic Removal of a Directing Group. Rhodium(III)-Catalyzed Entry into Indoles from N-Nitroso and α-Diazo-β-keto Compounds

A distinct C-H activation-based traceless synthetic protocol via electrophilic removal of a directing group is reported, complementing the currently exclusively used nucleophilic strategy. Rh(III)-catalyzed, N-nitroso-directed C-H activation allows the development of a traceless, atom- and step-economic, cascade approach for the synthesis of indole skeletons, starting from readily available N-nitroso and α-diazo-β-keto compounds. Importantly, the cyclization/denitrosation reaction represents a hitherto unobserved reactivity pattern for the N-nitroso group.

Intramolecular additions of various π-nucleophiles to chemoselectively activated amides and application to the synthesis of (±)-tashiromine

Vilsmeier-Haack type cyclizations proved to be particularly efficient for generating parts of the polycyclic cores of many alkaloids, although only monocyclizations have so far been reported. With the goal of rapidly and efficiently constructing polycycli

Synthesis of Cyclopenta[b]indol-1-ones and Carbazol-4-ones from N-(2-Halophenyl)-Substituted Enaminones by Intramolecular Heck Reaction

An efficient synthetic route towards N-methylated or nonmethylated 3,4-dihydrocyclopent[b]indol-1(2H)-ones (3) and 1,2,3,9-tetrahydrocarbazol-4(4H)-one (10) was elaborated, based on Pd-catalyzed intramolecular Heck reaction. The chemoselectivity of the cyclization was studied in the case of the bi- and trifunctional substrates 12 and 17, respectively. In the latter case, depending on the catalyst, either the brominated indole 18 or the tetracyclic compound 19 were obtained by single and double Heck reaction, respectively.

Photocyclization of aryl enaminones. An efficient route to indole alkaloid synthons

The photocyclization of enaminones was extended to aryl enaminones bearing a substituent on the aromatic moiety.This reaction was studied in order to achieve the synthesis of indole alkaloid synthons.Trials of regioselectivity control were made by using g