508169-20-8

Basic information

• Product Name: Carbonic acid, chloromethyl (5S)-6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b]pyrazin -5-yl ester
• CAS NO: 508169-20-8
• Molecular Formula: C13H8Cl2N4O4
• Molecular Weight: 355.137
• Mol File: 508169-20-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Carbonic acid, chloromethyl (5S)-6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b]pyrazin -5-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbonic acid, chloromethyl (5S)-6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b]pyrazin -5-yl ester(508169-20-8)
• EPA Substance Registry System: Carbonic acid, chloromethyl (5S)-6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b]pyrazin -5-yl ester(508169-20-8)

Safety Data

• Hazardous Substances Data: 508169-20-8(Hazardous Substances Data)

Upstream product

• 508169-18-4 (+/-)-7-(2-chloromethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one 
• 22128-62-7 carbonochloridic acid, chloromethyl ester 
• 43200-81-3 6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one 

Downstream Products

• 138729-47-2 eszopiclone 

Relevant articles and documents

Process for synthesis and purification of anhydrous crystalline S-zopiclone

Process for synthesis and purification of anhydrous crystalline S-zopiclone for the preparation of enantiomerically pure {S)-5-{chloromethyloxycarbonyloxy)-6-{5-chloropyrid-2-yl)-7-oxo-5,6-dihydropyrrolo[3,4b]pyrazine (S)-(I).

Enzymatic resolution of new carbonate intermediates for the synthesis of (S)-(+)-zopiclone

The lipase from Candida antarctica B catalyzes the enantioselective hydrolysis of (±)-6-(5-chloropyridin-2-yl)-7-chloromethyloxycarbonyloxy-6,7- dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one, a useful intermediate in the synthesis of (S)-(+)-zopiclone. This enzyme also catalyzes the resolution of the corresponding 2-chloroethylcarbonate derivative.