50820-58-1

Upstream product

• 1081-17-0 N-(4-methoxyphenyl)maleimide 
• 542-92-7 cyclopenta-1,3-diene 
• 104-94-9 4-methoxy-aniline 
• 129-64-6 3,6-endomethylene-1,2,3,6-tetrahydrophthalic anhydride 

Downstream Products

• 151766-89-1 (3R,3aR,4R,7S,7aS)-2,3,3a,4,7,7a-hexahydro-3-hydroxy-4,7-methano-2-(4-methoxyphenyl)-1H-isoindol-1-one 
• 158999-72-5 (3S,3aS,4S,7R,7aR)-2,3,3a,4,7,7a-hexahydro-3-hydroxy-4,7-methano-2-(4-methoxyphenyl)-1H-isoindol-1-one 
• 477248-70-7 C₁₆H₁₅NO₄ 
• 61800-57-5 2-exo-hydroxy-5-oxo-4-oxatricyclo[4.2.1.0^3,7]nonane-9-carboxylic acid 
• 158999-73-6 (3aS,4S,7R,7aR)-2,3,3a,4,7,7a-hexahydro-4,7-methano-2-(4-methoxyphenyl)-1H-isoindol-1-one 
• 151710-55-3 (3aR,4R,7S,7aS)-2,3,3a,4,7,7a-hexahydro-4,7-methano-2-(4-methoxyphenyl)-1H-isoindol-1-one 
• 845671-01-4 C₁₆H₁₇NO₅ 

Relevant academic research and scientific papers

Mechanochemical Grinding Diels-Alder Reaction: Highly Efficient and Rapid Access to Bi-, Tri-, and Tetracyclic Systems

Grinding of various electron-deficient dienophiles with diverse dienes in a pestle and mortar for 1-15 minutes afforded the corresponding Diels-Alder adducts in quantitative yields under catalyst-free and solvent-free conditions, without the necessity for

Desymmetrization of meso-cyclic imides via enantioselective monohydrogenation

meso-Cyclic imides are monohydrogenated to form the corresponding hydroxy lactams in 88-97% ee using trans-[Ru((R)-BINAP)(H)2((R,R)-dpen)] and related compounds as catalysts with base in THF. The hydrogenation proceeds with high enantiogroup-and chemoselectivity, and it is a desymmetrization reaction, forming up to five stereogenic centers in one reaction. Conversion of a hydroxy lactam into the corresponding iminium ion followed by addition of indene extended the number of stereogenic centers from 5 to 7.

Mechanochemical Diels-Alder cycloaddition reactions for straightforward synthesis of endo-norbornene derivatives

Under mechanochemical milling conditions, Diels-Alder cycloaddition of cyclopentadiene with maleic anhydride and maleimide derivatives proceeded very smoothly, affording endo-norbornenes exclusively in quantitative yield. All the transformations were accomplished at room temperature without using any catalyst or organic solvent, thus the workup and purification procedure is very simple. Control experiments on traditional and other tentative conditions were also investigated. Georg Thieme Verlag Stuttgart - New York.

Synthesis and antidepressant-like action of stereoisomers of imidobenzenesulfonylaziridines in mice evaluated in the forced swimming test

The present study describes the chemical synthesis and pharmacological evaluation of a new series of eleven compounds stereoisomers of imidobenzenesulfonylaziridines in the forced-swimming test (FST) in mice. The pharmacological results of these compounds

Synthesis and characterization of exo-endo and endo-endo benzenesulfonylaziridines

In the search for structural cyclic imide analogues of therapeutic interest, the synthesis, separation, and characterization of exo-endo 3 and endo-endo 4 stereoisomers of benzenesulfonylaziridines, not found in the literature, are described in this study