508201-90-9Relevant academic research and scientific papers
Subtle Microwave-Induced Overheating Effects in an Industrial Demethylation Reaction and Their Direct Use in the Development of an Innovative Microwave Reactor
De Bruyn, Mario,Budarin, Vitaliy L.,Sturm, Guido S. J.,Stefanidis, Georgios D.,Radoiu, Marilena,Stankiewicz, Andrzej,Macquarrie, Duncan J.
, p. 5431 - 5436 (2017)
A systematic study of the conventional and microwave (MW) kinetics of an industrially relevant demethylation reaction is presented. In using industrially relevant reaction conditions the dominant influence of the solvent on the MW energy dissipation is av
Multicyclic bis-amide MMP inhibitors
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Page/Page column 83, (2008/06/13)
The present invention relates generally to bis-amide group containing pharmaceutical agents, and in particular, to multicyclic bis-amide MMP-13 inhibitor compounds. More particularly, the present invention provides a new class of MMP-13 inhibiting compounds, containing a pyrimidinyl bis-amide group in combination with a heterocyclic moiety, that exhibit an increased potency and solubility in relation to currently known bis-amide group containing MMP-13 inhibitors.
