508209-67-4 Usage
Uses
Used in Organic Synthesis:
(3S, 4R)-1-AZA-BICYCLO[2.2.1]HEPT-3-YLAMINE serves as a valuable building block in organic synthesis, contributing to the creation of a variety of complex organic molecules. Its bicyclic amine structure allows for multiple points of attachment and reactivity, making it a versatile component in the synthesis of novel compounds.
Used in Drug Discovery:
In the field of drug discovery, (3S, 4R)-1-AZA-BICYCLO[2.2.1]HEPT-3-YLAMINE is utilized as a potential scaffold for the development of new therapeutic agents. Its unique structure and chiral nature offer opportunities for the design of innovative drugs with specific biological targets and activities.
Used in Medicinal Chemistry:
(3S, 4R)-1-AZA-BICYCLO[2.2.1]HEPT-3-YLAMINE is applied in medicinal chemistry as a key component in the synthesis of drug candidates. Its ability to be modified and functionalized allows researchers to explore its potential in treating various diseases and conditions.
Used in Asymmetric Catalysis:
The chiral nature of (3S, 4R)-1-AZA-BICYCLO[2.2.1]HEPT-3-YLAMINE makes it an intriguing candidate for asymmetric catalysis. It can be employed to create enantiomerically pure compounds, which are essential in the pharmaceutical industry for the development of drugs with fewer side effects and higher efficacy.
Used in Pharmaceutical Research:
In pharmaceutical research, (3S, 4R)-1-AZA-BICYCLO[2.2.1]HEPT-3-YLAMINE is explored for its potential as a precursor to new medications. Its unique structure and properties can be harnessed to develop drugs with improved pharmacokinetics, selectivity, and therapeutic potential.
Check Digit Verification of cas no
The CAS Registry Mumber 508209-67-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,0,8,2,0 and 9 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 508209-67:
(8*5)+(7*0)+(6*8)+(5*2)+(4*0)+(3*9)+(2*6)+(1*7)=144
144 % 10 = 4
So 508209-67-4 is a valid CAS Registry Number.
508209-67-4Relevant academic research and scientific papers
Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as α7 nicotinic acetylcholine receptor agonists
Walker, Daniel P.,Wishka, Donn G.,Piotrowski, David W.,Jia, Shaojuan,Reitz, Steven C.,Yates, Karen M.,Myers, Jason K.,Vetman, Tatiana N.,Margolis, Brandon J.,Jacobsen, E. Jon,Acker, Brad A.,Groppi, Vincent E.,Wolfe, Mark L.,Thornburgh, Bruce A.,Tinholt, Paula M.,Cortes-Burgos, Luz A.,Walters, Rodney R.,Hester, Matthew R.,Seest, Eric P.,Dolak, Lester A.,Han, Fusen,Olson, Barbara A.,Fitzgerald, Laura,Staton, Brian A.,Raub, Thomas J.,Hajos, Mihaly,Hoffmann, William E.,Li, Kai S.,Higdon, Nicole R.,Wall, Theron M.,Hurst, Raymond S.,Wong, Erik H.F.,Rogers, Bruce N.
, p. 8219 - 8248 (2007/10/03)
A novel set of azabicyclic aryl amides have been identified as potent and selective agonists of the α7 nAChR. A two-pronged approach was taken to improve the potential hERG liability of previously disclosed α7 nAChR agonist, PNU-282,987, while maintaining the compound's other desirable pharmacological properties. The first approach involved further exploration of the aryl carboxylic acid fragment of PNU-282,987, while the second approach focused on modification of the azabicyclic amine portion of PNU-282,987. The best compounds from each series are characterized by rapid brain penetration, good oral bioavailability in rat, and demonstrate in vivo efficacy in a rat P50 auditory sensory gating assay. At least one analog from each series (1h, 1o, 2a, 9a, and 18a) shows an improved hERG safety profile over PNU-282,987.
