508232-50-6Relevant academic research and scientific papers
Organocatalytic vinylogous Mannich reaction of trimethylsiloxyfuran with isatin-derived benzhydryl-ketimines
Rainoldi, Giulia,Sacchetti, Alessandro,Silvani, Alessandra,Lesma, Giordano
, p. 7768 - 7776 (2016)
A family of chiral quaternary 3-aminooxindole butenolides has been synthesized by BINOL-derived phosphoric acid-catalyzed addition of trimethylsiloxyfuran to isatin-derived ketimines. Such a vinylogous Mannich-type reaction was found to produce diastereoisomeric butenolides in good yields and in most cases high enantiomeric excesses. The configurational assignment of the obtained products was safely performed by chemical correlation. A computational study of the transition state allowed rationalizing the obtained stereochemical outcome, highlighting the possible binding modes of the catalyst-imine-nucleophile transition complex.
Leucine rich repeat kinase 2 (LRRK2) inhibitors based on indolinone scaffold: Potential pro-neurogenic agents
Salado, Irene G.,Zaldivar-Diez, Josefa,Sebastian, Victor,Li, Lingling,Geiger, Larissa,González, Silvia,Campillo, Nuria E.,Gil, Carmen,Morales, Aixa V.,Perez, Daniel I.,Martinez, Ana
, p. 328 - 342 (2017/07/07)
Leucine-rich repeat kinase 2 (LRRK2) is one of the most pursued targets for Parkinson's disease (PD) therapy. Moreover, it has recently described its role in regulating Wnt signaling and thus, it may be involved in adult neurogenesis. This new hypothesis
Evaluation of N-(2-thienylidene)amines, N-(2-hydroxybenzylidene)amines and 3-iminoindolin-2-ones as antileishmanial agents
Al-Kahraman, Yasser M.S.A.,Singh, Girija S.,Yasinzai, Masoom
experimental part, p. 491 - 495 (2012/06/18)
The paper describes the synthesis and antileishmanial activity of N-substituted imines, obtained from the reactions of primary amines with three biologically important aldehydes/ketones, thiophene-2-carbaldehyde, 2- hydroxybenzaldehyde (salicylaldehyde) and indoline-2,3-dione. Of the fourteen compounds screened from three classes, five compounds showed significant antileishmanial activity. Among the three classes of imines, the class of N-(2- thienylidene)amines showed much better activity than the other two classes. N-(2-Thienylidene)benzhydrylamine showed IC50 value of 0.51 μg/ml. The effect of substituents on the bioactivity is discussed.
