50825-99-5Relevant academic research and scientific papers
INHIBITORS OF NECROPTOSIS
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Page/Page column 59-60, (2016/09/22)
The invention relates to novel heterocyclic compounds of Formula (I) which inhibit necroptosis and methods for their use. The compounds may be useful in the treatment of conditions associated with deregulated necroptosis.
Novel pyrazolo[1,5-a]pyridines as PI3K inhibitors: Variation of the central linker group
Kendall, Jackie D.,Marshall, Andrew J.,Giddens, Anna C.,Tsang, Kit Yee,Boyd, Maruta,Frederick, Raphael,Lill, Claire L.,Lee, Woo-Jeong,Kolekar, Sharada,Chao, Mindy,Malik, Alisha,Yu, Shuqiao,Chaussade, Claire,Buchanan, Christina M.,Rewcastle, Gordon W.,Baguley, Bruce C.,Flanagan, Jack U.,Denny, William A.,Shepherd, Peter R.
supporting information, p. 41 - 46 (2014/01/06)
As part of our investigation into the pyrazolo[1,5-a]pyridines as novel PI3K inhibitors, we report a range of analogues where the central linker portion of the molecule was varied while retaining the pyrazolo[1,5-a]pyridine and arylsulfonyl or arylcarbonyl groups. Isostere generating software BROOD was used to assist with producing ideas. The isoform selectivity of the compounds varied from pan-PI3K for compound 41 to p110α-selective for compound 58 or p110δ-selective for compound 57. The latter two compounds varied only in their sulphur oxidation state.
