50832-49-0

Upstream product

• 7189-72-2 2-benzyl-5-nitro-1H-benzo[d]imidazole 
• 103-82-2 phenylacetic acid 
• 99-56-9 4-Nitrophenylene-1,2-diamine 

Downstream Products

• 33140-62-4 5-Amino-2-(α-hydroxybenzyl)benzimidazole 
• 108281-75-0 Methyl 2-(α-Methoxybenzyl)benzimidazole-5-carbamate 
• 108281-74-9 Methyl 2-(α-Hydroxybenzyl)benzimidazole-5-carbamate 
• 5086-55-5 2-(α-hydroxybenzyl)-5(6)-nitrobenzimidazole 

Relevant academic research and scientific papers

Metal-free aerobic oxidation of benzazole derivatives

2-Benzyl benzothiazoles and benzimidazoles are easily oxidized under air and basic conditions to give the corresponding ketones in good yields. The use of palladium acetate as a catalyst has little effect and even gives, in some cases, much lower yields.

Practicable Syntheses of 2-Hydroxymethyl-substituted Benzimidazoles and 2-Formylbenzimidazole

N-Protection of benzimidazole by a diethoxymethyl group, as in , allows exclusive lithiation at the 2-position.This protected anion can be made to react with various electrophiles (e. g. ketones, aldehydes) to yield the corresponding 2-hydroxymethylbenzimidazoles (1).Facile deprotection occurs with acid.Two practicable syntheses of 2-formylbenzimidazole are also described and an indirect route to benzimidazole-2-alcohols is discussed.