50835-95-5Relevant academic research and scientific papers
Microwave-assisted synthesis of 1,3-benzodioxole derivatives from catechol and ketones or aldehydes
Pingali, Subramanya R.K.,Jursic, Branko S.
experimental part, p. 4371 - 4374 (2011/09/19)
An efficient synthetic procedure for the preparation of a diverse library of 1,3-benzodioxoles was developed by applying controlled microwave heating in comparison with currently available conventional heating. Reactions were completed in less than 3 h. The isolation of product is simple, the isolated yields are good to excellent, and this method is applicable to large scale production.
Phosphine-initiated general base catalysis: Facile access to benzannulated 1,3-diheteroatom five-membered rings via double-Michael reactions of allenes
Szeto, Judy,Sriramurthy, Vardhineedi,Kwon, Ohyun
supporting information; experimental part, p. 5420 - 5423 (2011/11/29)
General base-catalyzed double-Michael reactions of allenes with various dinucleophiles are described. The reactions are facilitated most efficiently by a catalytic amount of trimethylphosphine, affording six types of C2-functionalized benzannulated five-m
Montmorillonite clay catalysis. Part 14. A facile synthesis of 2-substituted and 2,2-disubstituted 1,3-benzodioxoles
Li, Tong-Shuang,Li, Li-Jun,Lu, Bo,Yang, Feng
, p. 3561 - 3564 (2007/10/03)
A series of 2-substituted and 2,2-disubstituted 1,3-benzodioxoles have been synthesised by reaction of catechol and pyrogallol with corresponding aldehydes and ketones catalysed by montmorillonite KSF or K-10. The reactions are completed within 2.7-24 h to give satisfactory yields. Ketones give better yields than aldehydes, although highly sterically hindered ketones and diaryl ketones fail to react at all.
An Improved Method for the Synthesis of 2,2-disubstituted and 2-Monosubstituted 1,3-Benzodioxoles
Cole, Edward R.,Crank, George,Minh, H. T. Hai
, p. 675 - 680 (2007/10/02)
The reactions of catechol with ketones and aldehydes have been studied and convenient procedures have been developed for the preparation of the title compounds in high yields.These products undergo virtually quantitative nitration at position 5, thus providing a source of derivatives substituted in the benzene ring.
