50841-49-1

Upstream product

• 100-44-7 benzyl chloride 
• 51863-60-6 3,5-dihydroxyacetophenone 
• 28924-18-7 2-bromo-1-[3,5-bis(phenylmethoxy)phenyl]ethanone 
• 28924-21-2 3,5-dibenzyloxyacetophenone 

Downstream Products

• 23031-25-6 terbutaline 
• 28924-25-6 1-[3,5-bis(benzyloxy)phenyl]-2-(tert-butylamino)ethanol 

Relevant academic research and scientific papers

Preparation method of terbutaline sulfate (by machine translation)

The method adopts,hydroxyacetophenone as the starting material 3,5 - to obtain, di 3,5 -benzyloxyacetophenone, 3,5 - dibenzyloxyacetophenone and then generates, DMSO-benzyloxy 3,5 -phenyl,tert-butylamino 1 - [3,5 - ethanol (by hydrogenation debenzil) and sulfuric acid into a salt to obtain dibenzyloxybenzenethanone aldehyde] - 2 - (and then reductive amination with tertiary butylamine.) reaction conditions under, reaction conditions, are avoided, The method disclosed by the invention is cheap and easy to obtain and avoids the use of high-risk highly-toxic agents, by reductive amination . The method disclosed by the invention is low, reaction conditions . The method disclosed by the invention is cheap and easily available. (by machine translation)

Method for synthesizing terbutaline

The invention discloses a method for synthesizing terbutaline. The method comprises the following steps: reacting a compound I with selenium dioxide to obtain a compound II; reacting the compound II with tert-butylamine to obtain a compound III; reacting the compound III with a reducing agent to obtain a compound IV; and reacting the compound IV with a catalyst to remove benzyloxy to obtain terbutaline. The synthesis method has the advantage that the generation of impurity alpha-bromo-3, 5-dibenzyloxyacetophenone is avoided.