50841-50-4

Usage

InChI:InChI=1/C10H11BrO3/c1-13-8-3-7(10(12)6-11)4-9(5-8)14-2/h3-5H,6H2,1-2H3

Upstream product

• 51863-60-6 3,5-dihydroxyacetophenone 
• 74-88-4 methyl iodide 
• 17213-57-9 3,5-dimethoxybenzoyl chloride 
• 17213-59-1 2-diazo-1-(3,5-dimethoxyphenyl)ethanone 
• 39151-19-4 1-(3,5-dimethoxyphenyl)ethan-1-one 

Downstream Products

• 1015756-73-6 C₁₃H₁₂N₂O₂S 
• 54888-59-4 5-methoxy-2-(3,5-dimethoxyphenyl)-1H-indole 
• 1034366-57-8 5,7-dimethoxy-2-(3,5-dimethoxyphenyl)-1H-indole 
• 1180491-77-3 methyl 3-(2-(3,5-dimethoxyphenyl)-2-oxoethoxy)-5-methoxybenzoate 
• 1180491-86-4 3-(3,5-dimethoxyphenyl)-(6-methoxy-2-(4-methoxyphenyl)-benzofuran-4-yl) methanol 
• 107523-43-3 3-(3,5-dimethoxy-benzoyl)-1,1-dioxo-2,3-dihydro-1λ⁶-benzo[e][1,2]thiazin-4-one 
• 101878-62-0 2-(β-hydroxy-3,5-dimethoxy-phenethyl)-1,1-dioxo-1λ⁶-benz[d]isothiazol-3-one 
• 101589-24-6 1-(3,5-dimethoxy-phenyl)-2-methylamino-ethanol 

Relevant academic research and scientific papers

Total synthesis of the active resveratrol dimer dehydro-δ-viniferin

A new approach for the total synthesis of the active stilbene dimer dehydro-δ-viniferin has been achieved in 9 steps with methyl 4-hydroxybenzoate and 3,5-dihydroxyacetophenone as starting materials. The key feature of the method is the amberlyst 15-mediated cyclodehydration of α-aryloxyketone.

Synthesis method of terbutaline and application of terbutaline in preparation of terbutaline sulfate

The invention discloses a synthesis method of terbutaline, which is characterized by comprising the following steps: (1) reacting 3, 5-dimethoxyacetophenone with tetrabutylammonium tribromide to obtain 2-bromo-1-(3, 5-dimethoxyphenyl)ethanone; (2) reactin

Nucleus-independent chemical shift (NICS) as a criterion for the design of new antifungal benzofuranones

The assertion made by Wu et al. that aromaticity may have considerable implications for molecular design motivated us to use nucleus-independent chemical shifts (NICS) as an aromaticity criterion to evaluate the antifungal activity of two series of indol-4-ones. A linear regression analysis of NICS and antifungal activity showed that both tested variables were significantly related (p –1 for Candida glabrata, Candida krusei and Candida guilliermondii with compounds 15-32, 15-15 and 15-1. The MIC for filamentous fungi was 1.95 μg·mL–1 for Aspergillus niger for compounds 15-1, 15-33 and 15-34. The results obtained support the use of NICS in the molecular design of compounds with antifungal activity.

A PROCESS FOR THE PREPARATION PUERARIAFURAN

The present invention relates to a chemical method for producing puerariafuran, which is separated from Pueraria thunbergiana having various physiological activities, and derivatives thereof. The chemical method for producing puerariafuran and derivatives

Total synthesis of the resveratrol oligomers (±)-Ampelopsin B and (±)-σ-Viniferin

The total synthesis of the resveratrol dimers (±)-ampelopsin B and (±)-σ-viniferin is reported. Highlights of the approach include the use of cyclopropylmethyl groups to protect aromatic alcohols. This group allows an acid promoted three-step, one-pot dep

A facile and practical total synthetic route for ampelopsin F and permethylated ?-viniferin

Stilbene dimers (±)-ampelospin F and permethylated (±)-?-viniferin were synthesized by a practical synthetic route with overall yields of 10% and 27%. This route involves triethylsilane-mediated reduction of the 2,3-diarylbenzofuran, and BBr3-mediated one-pot demethylation and cascade intramolecular cyclization reaction.

First synthesis and anti-inflammatory effects of puerariafuran and its derivatives

The total synthesis of puerariafuran and its derivatives was achieved for the first time by the direct reaction between substituted α-bromoacetophenones and resorcinol. The reaction was mediated by neutral alumina and was fully regio-controlled. Subsequen

UREA COMPOUNDS AND THEIR USE AS FAAH ENZYME INHIBITORS

There is provided a compound having Formula I:(I) wherein: R1 is aryl which is optionally substituted with one or more groups selected from hydroxyl, halogen and C1-4 alkoxy, or R1 is aryl which is substituted with a second aryl group or an aryloxy group, wherein the second aryl group or the aryloxy group is optionally substituted with one or more groups selected from hydroxyl, halogen and C1-4 alkoxy; R2 is C1-4 alkyl; R3 is selected from hydroxyl and OSO2CH3; R4 and R5 are independently selected from hydrogen, hydroxyl and halogen; and n is 0 or 1; or a pharmaceutically acceptable salt thereof; wherein when R3 is hydroxyl and R4 and R5 are not hydroxyl, the optionally substituted aryl group, second aryl group or aryloxy group of R1 is substituted with one or more hydroxyl groups or C1-4 alkoxy groups, or wherein when R3 is hydroxyl, one of R4 and R5 is hydroxyl, provided that the compound is not N-(1-benzylpiperidin-4-yl)-4-(3,4-dihydroxyphenyl)-N-methyl-1H-imidazole-1-carboxamide hydrobromide. The compound may be used as an inhibitor of fatty acid amide hydrolase.

FUNGICIDAL DIPHENYL-SUBSTITUTED PYRIDAZINES

Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, wherein R1, R2, R3, R4a, R4b, R5, W, m and n are as defined in the disclosure. Also disclosed

A versatile approach to oligostilbenoid natural products - Synthesis of permethylated analogues of viniferifuran, malibatol A, and shoreaphenol

A highly practical route to oligostilbenoid natural products is described. A regioselective Bi(OTf)3-catalyzed cyclodehydration provided ready access to 3-arylbenzofuran. Pd-catalyzed direct C-H activation of benzofuran and subsequent cross-cou