50845-64-2Relevant academic research and scientific papers
Light-Mediated Formal Radical Deoxyfluorination of Tertiary Alcohols through Selective Single-Electron Oxidation with TEDA2+.
Aguilar Troyano, Francisco José,Ballaschk, Frederic,Jaschinski, Marcel,?zkaya, Yasemin,Gómez-Suárez, Adrián
supporting information, p. 14054 - 14058 (2019/11/11)
The synthesis of tertiary alkyl fluorides through a formal radical deoxyfluorination process is described herein. This light-mediated, catalyst-free methodology is fast and broadly applicable allowing for the preparation of C?F bonds from (hetero)benzylic, propargylic, and non-activated tertiary alcohol derivatives. Preliminary mechanistic studies support that the key step of the reaction is the single-electron oxidation of cesium oxalates—which are readily available from the corresponding tertiary alcohols—with in situ generated TEDA2+. (TEDA: N-(chloromethyl)triethylenediamine), a radical cation derived from Selectfluor.
LaCl3·2LiCl-catalyzed addition of Grignard reagents to ketones
Metzger, Albrecht,Gavryushin, Andrei,Knochel, Paul
experimental part, p. 1433 - 1436 (2009/10/17)
The addition of Grignard reagents to ketones using substoichiometric amounts of LaCl3·2LiCl was studied. Catalytic amounts of LaCl3·2LiCl (30 mol%) provide, in most cases, yields similar to those obtained using a stoichiometric amoun
