50868-86-5

Upstream product

• 548-93-6 3-hydroxyanthranilic acid 
• 5060-53-7 8-hydroxy-2-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone 
• 74-88-4 methyl iodide 
• 1319735-56-2 8-acetyloxy-2-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone 
• 3177-80-8 2-amino-3-methoxybenzoic acid 
• 54905-94-1 8-methoxy-2-methyl-4H-benzo[d][1,3]oxazin-4-one 
• 95-53-4 o-toluidine 

Relevant academic research and scientific papers

Synthesis and anticonvulsant evaluation of some novel 4(3H)-quinazolinones

A series of novel quinazoline derivatives, methaqualone analogs, were synthesized, evaluated for their anticonvulsant activity against electrically and chemically (pentylenetetrazole, picrotoxin, and strychnine) induced seizures and compared with the stan

Atropisomeric quinazolin-4-one derivatives are potent noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists

Piriqualone (1) was found to be an antagonist of AMPA receptors. Structure-activity optimization was conducted on each of the three rings in 1 to afford a series of potent and selective antagonists. The sterically crowded environment surrounding the N-3 aryl group provided sufficient thermal stability for atropisomers to be isolated. Separation of these atropisomers resulted in the identification of (+)-38 (CP-465,022), a compound that binds to the AMPA receptor with high affinity (IC50 = 36 nM) and displays potent anticonvulsant activity.