50869-62-0Relevant academic research and scientific papers
Phospholane-catalyzed wittig reaction
Werner, Thomas,Hoffmann, Marcel,Deshmukh, Sunetra
, p. 3286 - 3295 (2015/05/20)
We identified 2-phenylisophosphindoline 2-oxide as a suitable and potentially tunable catalyst for the catalytic Wittig reaction of aldehydes with activated organohalides. This catalyst was obtained by a straightforward two-step synthesis. Trimethoxysilane proved to be an efficient reducing agent for the in situ generation and regeneration of the catalyst from the corresponding phosphane oxide. Sodium carbonate was identified as a suitable base for the transformation. It is noteworthy that the particle size of the sodium carbonate had a tremendous effect on the outcome of the reaction. Under the optimized reaction conditions, 23 aldehydes were converted into the corresponding alkenes in high isolated yields of up to 88%. Moreover, an asymmetric catalytic Wittig reaction was performed for the desymmetrization of a prochiral diketone.
Conversion of Phosphinic into Phosphinous Esters through Nickelocene Reduktion-complexation of Phosphinothioic O-Esters. A New Synthesis of Carbon-phosphorus Heterocycles
Mathey, Francois,Mercier, Francois
, p. 191 - 192 (2007/10/02)
A new procedure for reducing a phosphinate (LO) into the corresponding phosphinite (L) includes the following steps: LO -> LS -> CpNi(I)L -> NiL4 -> L (Cp = cyclopentadiene); such as scheme is illustrated by the syntheses of 2-phenyl-1,2-oxaphospholane an
