50874-17-4

Upstream product

• 536-74-3 phenylacetylene 
• 2579-22-8 Phenylpropargyl aldehyde 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 

Downstream Products

• 1350307-77-5 1,4-diphenyl-2-(2-phenylvinylidene)butane-1,4-dione 
• 1447990-51-3 bis(5-phenyl-1-tosyl-1H-pyrazol-4-yl)methanone 

Relevant academic research and scientific papers

Cycloaddition Reaction of α,β-Alkynic Hydrazones and KSCN under Transition-Metal-Free Conditions: Synthesis of N-Iminoisothiazolium Ylides

A novel heteroannulation reaction between α,β-alkynic hydrazones and potassium thiocyanate has been developed for the synthesis of N-iminoisothiazolium ylides. The transformation features wide substrate scope, functional tolerance, and easy operation. This investigation involves a [4 + 1]-type cycloaddition reaction and C-S/S-N bond formation under transition-metal-free conditions. The application of this transformation to the gram-scale preparation of the N-imide ylide is also accomplished.

Cyclization-carbonylation-cyclization coupling reaction of α,β-alkynic hydrazones with palladium(ii)-bisoxazoline catalyst

A cyclization-carbonylation-cyclization coupling reaction (CCC-coupling reaction) of α,β-alkynic hydrazones, catalyzed by (box)Pd II complexes, afforded symmetrical ketones bearing two pyrazole groups in good to excellent yields. This method is applicable to a broad range of substrates.