50877-87-7

Upstream product

• 14575-62-3 5-methyl-1-phenyl-1,2-dihydro-pyrazol-3-one 
• 74-88-4 methyl iodide 
• 141-97-9 ethyl acetoacetate 
• 622-36-6 1-methyl-2-phenylhydrazine 
• 105-45-3 acetoacetic acid methyl ester 

Downstream Products

• 100135-02-2 4-hydroxymethyl-2,5-dimethyl-1-phenyl-1,2-dihydro-pyrazol-3-one 
• 21627-80-5 2,5-dimethyl-1-phenyl-4-(2,2,2-trichloro-1-hydroxy-ethyl)-1,2-dihydro-pyrazol-3-one 
• 102317-36-2 2,5-dimethyl-3-oxo-1-phenyl-2,3-dihydro-1H-pyrazole-4-carbaldehyde 
• 86635-76-9 3-chloro-5-methyl-1-phenyl-1H-pyrazole 
• 132624-50-1 4-(2,5-dimethyl-3-oxo-1-phenyl-2,3-dihydro-1H-pyrazole-4-carbonyl)-morpholine 
• 111666-14-9 4-trans-cinnamoyl-2-methyl-1-phenyl-1,2-dihydro-pyrazol-3-one 
• 110443-30-6 2,5-dimethyl-3-oxo-1-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid anilide 
• 101938-94-7 2,5-dimethyl-3-oxo-1-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid ethyl ester 
• 100720-03-4 2,5-dimethyl-3-oxo-1-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid ethylamide 
• 100120-58-9 2,5-dimethyl-3-oxo-1-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid hydrazide 
• 100795-43-5 2,5-dimethyl-3-oxo-1-phenyl-2,3-dihydro-1H-pyrazole-4-carbothioic acid S-methyl ester 
• 108239-37-8 2,5-dimethyl-3-oxo-1-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid methyl ester 
• 104509-54-8 2,5-dimethyl-3-oxo-1-phenyl-2,3-dihydro-1H-pyrazole-4-carbothioic acid 
• 105339-37-5 2,5-dimethyl-3-oxo-1-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid amide 

Relevant academic research and scientific papers

New pyrazolones as 11b-HSD1 inhibitors for diabetes

Compounds of formula as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R4 have the significance given in claim 1 can be used in the form of pharmaceutical compositions.

Mechanisms of Heterocycle Ring Formation. Part 5. A Carbon-13 Nuclear Magnetic Resonance Study of Pyrazolinone Synthesis by the Reaction of β-Ketoesters with Substituted Hydrazines

The 16 reactions between each of four hydrazines and four β-ketoesters have been followed by 13C n.m.r. spectroscopy.Peaks were assigned to starting materials, intermediates, and products, and reaction mechanisms determined and rationalized.Most rections proceed by attack of the least hindered hydrazine nitrogen atom on the keto carbon group of the ketoester.Relative rates of nucleophilic attack determine the build-up of intermediate and in some cases the nature of the products formed.