50901-42-3Relevant articles and documents
BENZIMIDAZOLE DERIVATIVES AND METHODS OF USE THEREOF
-
, (2008/12/08)
The present invention relates to compounds of formula (I); compositions comprising the compounds, and methods of using the compounds to treat or prevent pain, diabetes, a diabetic complication, impaired glucose tolerance (IGT) or impaired fasting glucose
INDOLE DERIVATIVES USEFUL AS HISTAMINE H3 ANTAGONISTS
-
Page 24, (2010/02/06)
Disclosed are novel compounds of the formula I wherein M1 is CH or N and M2 is C(R3) or N; R1 is optionally substituted indolyl or an aza derivative thereof; R2 is optionally substituted aryl or heteroaryl; and the remaining variables are as defined in the specification. Also disclosed are pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of treating various diseases or conditions, such as, for example, allergy, allergy-induced airway responses, and congestion (e.g., nasal congestion) using the compounds of Formula I. Also disclosed are methods of treating various diseases or conditions, such as, for example, allergy, allergy-induced airway responses, and congestion (e.g., nasal congestion) using the compounds of formula I in combination with a H1 receptor antagonist.
Substitution des 1,2-Diazinsystems mit symm.Trioxanylradikalen; ein Zugang zu Pyridazincarbaldehyden. 13. Mitteilung ueber Pyridazine
Heinisch, Gottfried,Kirchner, Ingrid
, p. 1501 - 1504 (2007/10/02)
Pyridazine (1) and 3-methylpyridazine (5) selectively are attacked by symm.trioxanyl radicals in positions 4 and/or 5 yielding 2, 3, 6, 7, 8, while 4-methylpyridazine (10) under similar conditions reacts to give not only C-5 substitution product 11, but also 3- and/or 6-trioxanylsubstituted methylpyridazines 12-15.The structures of the isomeric compounds were confirmed on basis of pmr-data.By hydrolysis of 6, 11, and 12 the unknown formylmethylpyridazines 9, 16 and 17 were prepared.Compound 16 was found to undergo intermolecular aldol-type addition easily yielding lactol 18.Synthesis of pyridazinecarboxaldehyde (4) starting from 1 is presented.