50903-61-2

Basic information

• Product Name: L-Methionine, N-[(1,1-dimethylethoxy)carbonyl]-, pentafluorophenyl ester
• CAS NO: 50903-61-2
• Molecular Formula: C16H18F5NO4S
• Molecular Weight: 415.381
• Mol File: 50903-61-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-Methionine, N-[(1,1-dimethylethoxy)carbonyl]-, pentafluorophenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Methionine, N-[(1,1-dimethylethoxy)carbonyl]-, pentafluorophenyl ester(50903-61-2)
• EPA Substance Registry System: L-Methionine, N-[(1,1-dimethylethoxy)carbonyl]-, pentafluorophenyl ester(50903-61-2)

Safety Data

• Hazardous Substances Data: 50903-61-2(Hazardous Substances Data)

Upstream product

• 93000-03-4 N-(t-butoxycarbonyl)methionine 
• 771-61-9 2,3,4,5,6-pentafluorophenol 

Downstream Products

• 5920-14-9 N^α-tert-Butyloxycarbonyl-L-methionyl-L-aspartyl-L-phenylalanine amide 
• 140702-23-4 Boc-Met-Tyr(Bzl)-Pro-OH 
• 140702-18-7 Boc-Met-Thr(Bzl)-Thr(Bzl)-Ala-Gln-Gly-OH 
• 72658-50-5 L-methionine pentafluorophenyl ester hydrochloride 
• 66438-52-6 N-carbobenzoxyglycyl-L-methionine pentafluophenyl ester 
• 72658-56-1 N-carbobenzoxyglycyl-L-methionyl-L-valine methyl ester 
• 88888-68-0 Z-pGlu-Met-Pro-NH₂ 
• 63229-05-0 L-Methionyl-L-aspartyl-L-phenylalanine amide trifluoroacetate 
• 210777-25-6 (S)-2-{2-[(R)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-5-((S)-2-tert-butoxycarbonylamino-4-methylsulfanyl-butyrylamino)-pentanoylamino]-acetylamino}-3-phenyl-propionic acid 
• 10332-17-9 Met-OMe 

Relevant articles and documents

Kinetic Studies in Peptide Chemistry. Coupling, Racemization, and Evaluation of Methods Useful for Shortening Coupling Time

Kinetic studies were carried out on N-protected methionine and glycylmethionine active esters to determine the racemization rate constants with triethylamine and the coupling rate constants with valine methyl ester.In contrast to cysteine dipeptide active esters, which racemize through an enolization mechanism, the methionine dipeptide active esters racemize through the usual 5(4H)-oxazolone route.The role of sulfur in the side chain is discussed.The time required for coupling a given percentage (e.g., 99 percent) of the amine component can be significantly reduced by using an excess of the active ester.This method is evaluated quantitatively for second-order kinetics.