50906-77-9Relevant articles and documents
A tri-responsive and fast self-healing organogel with stretchability based on multiple dynamic covalent bonds
Ren, Shujing,Liang, Huiqin,Sun, Panpan,Gao, Yanan,Zheng, Liqiang
, p. 1609 - 1614 (2020)
Smart self-healing materials have attracted much attention due to their promising applications in biological and medical fields. Here, a tri-responsive and fast self-healing organogel based on a boronate ester bond, an acylhydrazone bond and a disulfide bond was prepared from polyvinyl alcohol (PVA), 4-formylphenylboronic acid (FPBA), and 3,3′-dithiobis (propionohydrazide) (DPH). PVA was selected as a gel skeleton to improve the mechanical property of the organogel. A tensile test indicated that the obtained organogel is highly stretchable. Due to the dynamic nature of reversible covalent chemistry, the organogel can respond to pH, glucose and redox to undergo gel-sol phase transition. Microscopy observation and tensile tests further indicate that the organogel can self-repair without external stimuli.
Smart low molecular weight hydrogels with dynamic covalent skeletons
Sun, Panpan,Ren, Shujing,Liu, Fenglin,Wu, Aoli,Sun, Na,Shi, Lijuan,Zheng, Liqiang
, p. 6678 - 6683 (2018/08/28)
We report a new strategy for fabricating a smart low molecular weight hydrogel based on dynamic covalent chemistry from a bola-type supra-gelator, which was facilely fabricated in situ from two non-assembling building blocks, (3-(2-(4-formylphenoxy) ethyl)-1-methyl imidazolium bromide, MA) and (3,3′-dithiobis (propionohydrazide), DSPDZ), through dynamic acylhydrazone bonding. The obtained low molecular weight hydrogels exhibited redox-responsive and controllable self-healing properties. The role of dynamic covalent bonding in the formation of smart hydrogels is revealed in this study, which provides a simple and bottom-up method for constructing smart low molecular weight hydrogels.
Co-delivery of doxorubicin and P-glycoprotein siRNA by multifunctional triblock copolymers for enhanced anticancer efficacy in breast cancer cells
Xu, Minghui,Qian, Junmin,Suo, Aili,Cui, Ning,Yao, Yu,Xu, Weijun,Liu, Ting,Wang, Hongjie
, p. 2215 - 2228 (2015/04/27)
Combined treatment of chemotherapeutics and small interfering RNAs (siRNAs) is a promising therapy strategy for breast carcinoma via their synergetic effects. In this study, to improve the therapeutic effect of doxorubicin (DOX), novel triblock copolymers, folate/methoxy-poly(ethylene glycol)-block-poly(l-glutamate-hydrazide)-block-poly(N,N-dimethylaminopropyl methacrylamide) (FA/m-PEG-b-P(LG-Hyd)-b-PDMAPMA), were synthesized and used as a vehicle for the co-delivery of DOX and P-glycoprotein (P-gp) siRNA into breast cancer cells. The triblock copolymers were synthesized by a combination of ring-opening polymerization of γ-benzyl-l-glutamate-N-carboxyanhydride using cystamine-terminated heterotelechelic PEG derivatives possessing folate or methoxy end groups (FA/m-PEG-Cys) as initiators and reversible addition-fragmentation chain transfer polymerization of N,N-dimethylaminopropyl methacrylamide followed by hydrazinolysis. The successful synthesis of the copolymers was confirmed by 1H NMR and gel permeation chromatography. DOX was covalently conjugated onto the poly(l-glutamate-hydrazide) blocks via a pH-labile hydrazone linkage, and the DOX-conjugated triblock copolymers could self-assemble into nanoparticles in aqueous solutions. P-glycoprotein (P-gp) siRNA was then bound to the cationic poly(N,N-dimethylaminopropyl methacrylamide) (PDMAPMA) blocks through an electrostatic interaction, resulting in the formation of spherical nanocomplexes with an average diameter of 196.8 nm and a zeta potential of +28.3 mV. The in vitro release behaviors of DOX and siRNA from the nanocomplexes were pH- and reduction-dependent, and the release rates were much faster under a reductive acidic condition (pH 5.0, glutathione: 10 mM) simulating the intracellular endo-lysosomal environment of cancer cells compared to physiological conditions. The fast payload release rates were closely related to both the glutathione-triggered detachment of PEG blocks from the nanocomplex surface and the pH-sensitive cleavage of hydrazone linkages. FA-decorated nanocomplexes showed higher cellular uptake efficiency and cytotoxicity against MCF-7 cells than FA-free nanocomplexes, as confirmed by confocal laser scanning microscopy, transmission electron microscopy, MTT and flow cytometry analyses. Our results demonstrated that the multifunctional triblock copolymer-mediated co-delivery of DOX and P-gp siRNA might be a new promising therapeutic strategy for breast cancer treatment. This journal is
