50908-22-0

Basic information

• Product Name: (2E)-2-({(E)-[(4-methylphenyl)sulfonyl]diazenyl}methylidene)pyridin-1(2H)-ol
• CAS NO: 50908-22-0
• Molecular Formula: C₁₃H₁₃N₃O₃S
• Molecular Weight: 291.3256
• Mol File: 50908-22-0.mol

Chemical Properties

• Boiling Point: 450.5°C at 760 mmHg
• Flash Point: 226.3°C
• Density: 1.31g/cm³
• Vapor Pressure: 6.64E-09mmHg at 25°C
• Refractive Index: 1.619
• CAS DataBase Reference: (2E)-2-({(E)-[(4-methylphenyl)sulfonyl]diazenyl}methylidene)pyridin-1(2H)-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-2-({(E)-[(4-methylphenyl)sulfonyl]diazenyl}methylidene)pyridin-1(2H)-ol(50908-22-0)
• EPA Substance Registry System: (2E)-2-({(E)-[(4-methylphenyl)sulfonyl]diazenyl}methylidene)pyridin-1(2H)-ol(50908-22-0)

Safety Data

• Hazardous Substances Data: 50908-22-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
(2E)-2-((E)-[(4-methylphenyl)sulfonyl]diazenylmethylidene)pyridin-1(2H)-ol is used as a key intermediate in organic synthesis for the development of novel compounds with potential applications in various fields.
Used in Dye Chemistry:
In the dye industry, (2E)-2-((E)-[(4-methylphenyl)sulfonyl]diazenylmethylidene)pyridin-1(2H)-ol is utilized as a precursor for the synthesis of dyes and pigments, taking advantage of its azo group which is commonly found in these colorants.
Used in Pharmaceutical Research:
(2E)-2-((E)-[(4-methylphenyl)sulfonyl]diazenylmethylidene)pyridin-1(2H)-ol is employed as a compound of interest in pharmaceutical research, where its unique structure may contribute to the discovery of new drugs or drug candidates with therapeutic potential.

Relevant articles and documents

Antineoplastic and biochemical properties of arylsulfonylhydrazones of 2 formylpyridine N oxide

The structural parameters necessary for the antineoplastic potency of a new class of anticancer agents, arylsulfonylhydrazones of 2 formylpyridine N oxide, were examined in mice bearing Sarcoma 180 ascites cells. The findings indicated that (a) replacement of the pyridine ring with benzene quinoline, or isoquinoline resulted in loss of activity, (b) movement of the formylhydrazone side chain from the 2 to the 3 or 4 positions of the pyridine N oxide produced inactive agents, (c) the pyridine N oxide function was essential for anticancer activity, except for 4 substituted derivatives which were active without the N oxide group, (d) replacement of the SO2 group by CO resulted in complete loss of activity, and (e) a carbon atom could be inserted between the SO2 and aryl ring with retention of anticancer potency. One of the most active members of this series, 1 oxidopyridine 2 carboxaldehyde p toluenesulfonylhydrazone exhibited antineoplastic, activity against a broad spectrum of transplanted tumors including Sarcoma 180, Hepatoma 129, Ehrlich carcinoma, leukemia L1210, and a subline of Sarcoma 180 resistant to α (N) heterocyclic carboxaldehyde thiosemicarbazones. This agent caused inhibition of thymidine 3H and uridine 3H incorporation into DNA and RNA respectively, of Sarcoma 180 ascites cells; protein biosynthesis was relatively insensitive to the action of this compound.