509083-47-0Relevant academic research and scientific papers
Synthesis of lead LFA-1 antagonist [14C]spyrocyclic hydantoin
Tran, Scott B.,Maxwell, Brad D.,Chen, Shiang-Yuan,Bonacorsi, Samuel J.,Leith, Leslie,Ogan, Marc,Rinehart, J. Kent,Balasubramanian, Balu
experimental part, p. 236 - 242 (2010/06/16)
Radiolabelled drug lead candidate leukocyte function-associated antigen 1 antagonist [14C]spyrocyclic hydantoin: 5-(((5S,9R)-9-(4-[ 14C]-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3, 7-triazaspiro[4.4]nonan-7-yl)methyl)
Spiro-hydantoin compounds useful as anti-inflammatory agents
-
Page/Page column 39, (2008/06/13)
Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates, enantiomers, and diastereomers, and prodrugs thereof, are useful as inhibitors of LFA-1/ICAM and as anti-inflammatory agents, wherein L and K are O or S; Z is N or CR4b; Ar is an optionally-substituted aryl or heteroaryl; G is a linker attached to T or M or is absent; J, M and T are selected to define a three to six membered saturated or partially unsaturated non-aromatic ring; and R2 R4a, R4b, and R4c are as defined in the specification.
