509083-74-3Relevant academic research and scientific papers
Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): Structure-activity relationships leading to the identification of 6-((5 S,9 R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7- triazaspiro[4.4]nonan-7-yl)nico
Watterson, Scott H.,Xiao, Zili,Dodd, Dharmpal S.,Tortolani, David R.,Vaccaro, Wayne,Potin, Dominique,Launay, Michele,Stetsko, Dawn K.,Skala, Stacey,Davis, Patric M.,Lee, Deborah,Yang, Xiaoxia,McIntyre, Kim W.,Balimane, Praveen,Patel, Karishma,Yang, Zheng,Marathe, Punit,Kadiyala, Pathanjali,Tebben, Andrew J.,Sheriff, Steven,Chang, Chiehying Y.,Ziemba, Theresa,Zhang, Huiping,Chen, Bang-Chi,Delmonte, Albert J.,Aranibar, Nelly,McKinnon, Murray,Barrish, Joel C.,Suchard, Suzanne J.,Murali Dhar
scheme or table, p. 3814 - 3830 (2010/07/05)
Leukocyte function-associated antigen-1 (LFA-1), also known as CD11a/CD18 or αLβ2, belongs to the β2 integrin subfamily and is constitutively expressed on all leukocytes. The major ligands of LFA-1 include three intercellu
Synthesis of lead LFA-1 antagonist [14C]spyrocyclic hydantoin
Tran, Scott B.,Maxwell, Brad D.,Chen, Shiang-Yuan,Bonacorsi, Samuel J.,Leith, Leslie,Ogan, Marc,Rinehart, J. Kent,Balasubramanian, Balu
experimental part, p. 236 - 242 (2010/06/16)
Radiolabelled drug lead candidate leukocyte function-associated antigen 1 antagonist [14C]spyrocyclic hydantoin: 5-(((5S,9R)-9-(4-[ 14C]-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3, 7-triazaspiro[4.4]nonan-7-yl)methyl)
Discovery and development of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5- dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl-methyl] -3-thiophenecarboxylic Acid (BMS-587101) - A small molecule antagonist of leukocyte function associated antigen-1
Potin, Dominiques,Launay, Michele,Monatlik, Francoise,Malabre, Patrice,Fabreguettes, Maud,Fouquet, Andre,Maillet, Magali,Nicolai, Eric,Dorgeret, Lo?c,Chevallier, Fran?ois,Besse, Dominique,Dufort, Monique,Caussade, Fran?ois,Ahmad, Syed Z.,Stetsko, Dawn K.,Skala, Stacey,Davis, Patricia M.,Balimane, Praveen,Patel, Karishma,Yang, Zheng,Marathe, Punit,Postelneck, Jennifer,Townsend, Robert M.,Goldfarb, Valentina,Sheriff, Steven,Einspahr, Howard,Kish, Kevin,Malley, Mary F.,DiMarco, John D.,Gougoutas, Jack Z.,Kadiyala, Pathanjali,Cheney, Daniel L.,Tejwani, Ravindra W.,Murphy, Denette K.,Mcintyre, Kim W.,Yang, Xiaoxia,Chao, Sam,Leith, Leslie,Xiao, Zili,Mathur, Arvind,Chen, Bang-Chi,Wu, Daugh-Rurng,Traeger, Sarah C.,McKinnon, Murray,Barrish, Joel C.,Robl, Jeffrey A.,Iwanowicz, Edwin J.,Suchard, Suzanne J.,Dhar, T. G. Murali
, p. 6946 - 6949 (2007/10/03)
LFA-1 (leukocyte function-associated antigen-1), is a member of the β2-integrin family and is expressed on all leukocytes. This letter describes the discovery and preliminary SAR of spirocyclic hydantoin based LFA-1 antagonists that culminated in the iden
