50911-60-9

Usage

Uses

Used in Pharmaceutical Industry:
3-(4-chlorophenoxy)propan-1-amine is utilized as an intermediate in the synthesis of antidepressant drugs due to its function as a selective serotonin and norepinephrine reuptake inhibitor. Its ability to modulate neurotransmitter levels makes it a potential candidate for the development of medications aimed at treating depression and related disorders.
Used in Agricultural Chemicals:
In the agricultural sector, 3-(4-chlorophenoxy)propan-1-amine is employed as an active ingredient in the production of pesticides. Its insecticidal and herbicidal properties contribute to the control of pests and weeds, thereby enhancing crop protection and yield.
Used in Chemical Research:
3-(4-chlorophenoxy)propan-1-amine also serves as a valuable compound in chemical research, where it can be used to explore new synthetic pathways, investigate its biological activities further, and develop new applications in various fields.

InChI:InChI=1/C9H12ClNO/c10-8-2-4-9(5-3-8)12-7-1-6-11/h2-5H,1,6-7,11H2

Upstream product

• 5460-29-7 2-(3-bromopropyl)isoindole-1,3-dione 
• 106-48-9 4-chloro-phenol 
• 46125-42-2 3-(4-chlorophenoxy)propanenitrile 
• 681428-15-9 2-[3-(4-chlorophenoxy)propyl]-1H-isoindole-1,3(2H)-dione 

Downstream Products

• 103524-48-7 5-[3-(4-Chloro-phenoxy)-propylamino]-2-isopropyl-2-(3,4,5-trimethoxy-phenyl)-pentanenitrile 
• 100840-82-2 2-Amino-6-[3-(4-chloro-phenoxy)-propylamino]-5-nitroso-3H-pyrimidin-4-one 
• 103524-49-8 5-{[3-(4-Chloro-phenoxy)-propyl]-methyl-amino}-2-isopropyl-2-(3,4,5-trimethoxy-phenyl)-pentanenitrile 
• 1266246-54-1 1-(3-(4-chlorophenoxy)propyl)-6-(2-chlorophenyl)-1,6-dihydro-1,3,5-triazine-2,4-diamine hydrochloride 
• 1266246-42-7 1-(3-(4-chlorophenoxy)propyl)-6-(4-(trifluoromethyl)phenyl)-1,6-dihydro-1,3,5-triazine-2,4-diamine hydrochloride 
• 1266246-55-2 1-(3-(4-chlorophenoxy)propyl)-6-(4-methoxyphenyl)-1,6-dihydro-1,3,5-triazine-2,4-diamine hydrochloride 
• 1266246-56-3 6-(4-chloro-3-fluorophenyl)-1-(3-(4-chlorophenoxy)propyl)-1,6-dihydro-1,3,5-triazine-2,4-diamine hydrochloride 
• 1266246-57-4 1-(3-(4-chlorophenoxy)propyl)-6-(3-chlorophenyl)-1,6-dihydro-1,3,5-triazine-2,4-diamine hydrochloride 
• 1266246-77-8 1-(3-(4-chlorophenoxy)propyl)-6-(4-(trifluoromethylthio)phenyl)-1,6-dihydro-1,3,5-triazine-2,4-diamine hydrochloride 

Relevant academic research and scientific papers

COMPOUNDS AND USES THEREOF

Provided herein are compounds, such as compounds for use in treating cancer. Also provided are methods of treating cancer, including treatment resistant cancer or cancer associated with a hypoxic tumor.

CHEMCICAL COMPOUNDS

The invention is directed to substituted pyrrolidine derivatives. Specifically, the invention is directed to compounds according to Formula III: wherein A, B, L1, L2, L3, R1, R2, R3, R4, R5, R6, R9, R10, R30, Y1, Y2, z2, z4, z5, and z6 are as defined herein, and salts thereof. The compounds of the invention are inhibitors of the ATF4 pathway and can be useful in the treatment of cancer, pre-cancerous syndromes and diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease, spinal cord injury, traumatic brain injury, ischemic stroke, stroke, diabetes, Parkinson disease, Huntington's disease, Creutzfeldt-Jakob Disease, and related prion diseases, progressive supranuclear palsy, amyotrophic lateral sclerosis, myocardial infarction, cardiovascular disease, inflammation, fibrosis, chronic and acute diseases of the liver, chronic and acute diseases of the lung, chronic and acute diseases of the kidney, chronic traumatic encephalopathy (CTE), neurodegeneration, dementia, cognitive impairment, atherosclerosis, ocular diseases, arrhythmias, in organ transplantation and in the transportation of organs for transplantation. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting the ATF4 pathway and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

QUINOLINONE CARBOXAMIDE INHIBITORS OF ENDOTHELIAL LIPASE

The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.

Imidazole compounds

A novel class of imidazo heterocyclic compounds, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.

Therapeutic amines

Compounds of formula I, and their pharmaceutically acceptable salts, STR1 in which R1 and R2 are hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, phenylalkyl or alkenyl; or NR1 R2 is a heterocyclic group; A is trimethylene optionally substituted by alkyl and the phenyl ring is optionally substituted by substituents such as halogeno, alkenyl, amino, cyano, ureido, alkyl, carbamoylalkyl, alkanoylamino, alkoxycarbonyl, N-alkyl-alkanoylamino, alkanoyl and amines thereof; are inhibitors of squalene synthese and hence useful in treating diseases in which a lowering of cholesterol is desirable. As well as the use of these compounds in medicine, novel compounds, processes for their preparation and pharmaceutical compositions are also referred to.