50912-68-0Relevant academic research and scientific papers
Total Synthesis of Microcystin-LF and Derivatives Thereof
Zemskov, Ivan,Altaner, Stefan,Dietrich, Daniel R.,Wittmann, Valentin
, p. 3680 - 3691 (2017/04/11)
Microcystins (MCs) are highly toxic natural products which are produced by cyanobacteria. They can be released to the water during harmful algal blooms and are a serious threat to animals and humans. Described is the total synthesis of the cyanotoxin micr
Development of UV-responsive catch-and-release system of a cysteine protease model peptide
Shigenaga, Akira,Morishita, Ko,Yamaguchi, Keiko,Ding, Hao,Ebisuno, Koji,Sato, Kohei,Yamamoto, Jun,Akaji, Kenichi,Otaka, Akira
experimental part, p. 8879 - 8886 (2011/12/03)
Cysteine proteases are attractive drug targets due to their involvement in a wide variety of diseases. To evaluate the potential of a particular protease as a drug target, use of a reagent that controls activity of the protease is indispensable. In this context, we have developed a catch-and-release reagent that first forms a covalent bond with the active center thiol of a cysteine protease to suppress its activity and then is removed by UV-irradiation to release the parent active protease. In this paper, the design and synthesis of a catch-and-release reagent of thiols are described. Its application to caging (catch) and UV-induced uncaging (release) of a model peptide derived from an active site of caspase-9 and introduction of a recognition moiety on the reagent are also reported.
Design of the Synthetic Route for Peptides and Proteins Based on the Solubility Prediction Method. I. Synthesis and Solubility Properties of Human Proinsulin C-Peptide Fragments
Narita Mitsuaki,Ogura, Toshihiko,Sato, Kazuhiro,Honda, Shinya
, p. 2433 - 2438 (2007/10/02)
The usefulness of the solubility prediction method is demonstrated using relatively small peptide fragments of human proinsulin C-peptide.The propriety of the solubility prediction method for peptides having polar side chains is also examined in the following respects: (1) Peptide intermediates smaller than a heptapeptide have high solubility regardless of their c> values; (2) the c> values of peptide intermediates are useful for judging solubility of peptide intermediates equal to or larger than an octapeptide level; (3) the Pro residue in a central position of a peptide chain is effective for increasing peptide solubility; and (4) there is critical chain length for peptide insolubility caused by a β-sheet aggregation.A strategy suitable for the design of the synthetic route or human proinsulin C-peptide is subsequently discussed on the basis of the solubility prediction of peptide intermediates.
