509150-38-3

Basic information

• Product Name: ethyl 5-[(3,3-dimethylbutanoyl)-amino]-1-(2-fluorobenzyl)-1H-indole-2-carboxylate
• Synonyms: ethyl 5-[(3,3-dimethylbutanoyl)-amino]-1-(2-fluorobenzyl)-1H-indole-2-carboxylate
• CAS NO: 509150-38-3
• Molecular Weight: 410.488
• Mol File: 509150-38-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 5-[(3,3-dimethylbutanoyl)-amino]-1-(2-fluorobenzyl)-1H-indole-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 5-[(3,3-dimethylbutanoyl)-amino]-1-(2-fluorobenzyl)-1H-indole-2-carboxylate(509150-38-3)
• EPA Substance Registry System: ethyl 5-[(3,3-dimethylbutanoyl)-amino]-1-(2-fluorobenzyl)-1H-indole-2-carboxylate(509150-38-3)

Safety Data

• Hazardous Substances Data: 509150-38-3(Hazardous Substances Data)

Upstream product

• 509150-37-2 ethyl 5-amino-1-(2-fluorobenzyl)-1H-indole-2-carboxylate 
• 7065-46-5 3,3-dimethylbutanoic acid chloride 
• 509150-04-3 ethyl 1-(2-fluorobenzyl)-5-nitro-1H-indole-2-carboxylate 
• 446-48-0 o-fluorobenzyl bromide 
• 16732-57-3 5-nitro-indole-2-carboxylic acid ethyl ester 

Downstream Products

• 509149-89-7 3-({[5-[(3,3-dimethylbutanoyl)-amino]-1-(2-fluorobenzyl)-1H-indol-2-yl]-carbonyl}-amino)benzoic acid 
• 904295-32-5 5-{[5-(3,3-dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-1H-indole-2-carbonyl]-amino}-nicotinic acid methyl ester 
• 509149-38-6 5-[(3,3-dimethylbutanoyl)-amino]-1-(2-fluorobenzyl)-N-phenyl-1H-indole-2-carboxamide 
• 509150-40-7 5-[(3,3-dimethylbutanoyl)-amino]-1-(2-fluorobenzyl)-1H-indole-2-carboxylic acid 

Relevant articles and documents

Novel, selective indole-based ECE inhibitors: Lead optimization via solid-phase and classical synthesis

A novel class of indole-based endothelin-converting enzyme (ECE) inhibitors was identified by high throughput screening. We report systematic optimization of this compound class by means of classical and solid-phase chemistry. Optimized compounds with a bisarylamide side chain at the 2-position of the indole skeleton exhibit low-nanomolar activity on ECE.