50925-79-6
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Basic information
- Product Name: Colestipol
- Synonyms: Colestipol;COLESTIPOL - US DMF
- CAS NO:50925-79-6
- Molecular Formula: C11H28ClN5O
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: N/A
- Mol File: 50925-79-6.mol
- Article Data: 0
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 341.5°Cat760mmHg
- Flash Point: 185°C
- Appearance: /
- Density: g/cm3
- Vapor Pressure: 8.01E-05mmHg at 25°C
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: Colestipol(CAS DataBase Reference)
- NIST Chemistry Reference: Colestipol(50925-79-6)
- EPA Substance Registry System: Colestipol(50925-79-6)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 50925-79-6(Hazardous Substances Data)
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50925-79-6 Usage
Description
Colestipol, a synthetic, high molecular weight, anion-exchange resin, is primarily used for the treatment of high cholesterol levels in the body. It functions by binding to bile acids in the digestive tract, which are then eliminated from the body. This process leads to an increased liver production of bile acids, resulting in a reduced level of cholesterol in the blood.Uses
Used in Pharmaceutical Industry:Colestipol is used as a cholesterol-lowering agent for the treatment of hypercholesterolemia, a condition characterized by high levels of cholesterol in the blood. This can contribute to the development of atherosclerosis and arterial hypertension, which are significant risk factors for cardiovascular diseases.
Mechanism of action
Colestipol binds to bile acids, which are secreted from the organism in a form which bunds to the ion-exchange resin. It lowers the overall level of cholesterol and cholesterol-containing low-density lipoproteins in blood plasma while not affecting the level of high-density lipoproteins.Synthesis
Colestipol (20.1.1) is a hydrochloride of the product of copolymerization of epichlorohydrine with diethylentriamine that contains varying numbers of quaternary nitrogen atoms. There is no exact formula of the product of copolymerization, but its approximate structure can be expressed as 20.1.1.Check Digit Verification of cas no
The CAS Registry Mumber 50925-79-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,0,9,2 and 5 respectively; the second part has 2 digits, 7 and 9 respectively.Calculate Digit Verification of CAS Registry Number 50925-79:
(7*5)+(6*0)+(5*9)+(4*2)+(3*5)+(2*7)+(1*9)=126
126 % 10 = 6
So 50925-79-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H23N5.C3H5ClO/c9-1-3-11-5-7-13-8-6-12-4-2-10;4-1-3-2-5-3/h11-13H,1-10H2;3H,1-2H2
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Colestipol
