5093-29-8

Upstream product

• 82655-60-5 N-(Morpholino-thiocarbonyl)benzimidchlorid 
• 62-53-3 aniline 
• 93-98-1 N-phenyl benzoyl amide 
• 110-91-8 morpholine 
• 4903-36-0 N-phenyl-benzimidoyl chloride 
• 592-87-0 lead(II) thiocyanate 
• 20800-27-5 N-phenyl-benzimidoyl isothiocyanate 

Downstream Products

• 104355-36-4 N-[1-Morpholin-4-yl-1-pyrrolidin-1-yl-meth-(Z)-ylidene]-N'-phenyl-benzamidine 
• 104355-35-3 N-[1-Morpholin-4-yl-1-piperidin-1-yl-meth-(Z)-ylidene]-N'-phenyl-benzamidine 
• 104355-34-2 N-(Di-morpholin-4-yl-methylene)-N'-phenyl-benzamidine 
• 128652-27-7 N-{Phenyl-[(E)-phenylimino]-methyl}-morpholine-4-carboximidothioic acid ethyl ester 
• 128652-23-3 1,2-diphenyl-4-methylthio-4-morpholino-1,3-diaza-1,3-butadiene 
• 133858-59-0 5-chloro-1,2-diphenyl-4-morpholino-1,6-dihydrpyrimidin-6-one 
• 104355-34-2 N-(Di-morpholin-4-yl-methylene)-N'-phenyl-benzamidine 
• 133858-39-6 4-morpholino-1,2,5-triphenyl-1,6-dihydropyrimidin-6-one 
• 1108616-28-9 5-morpholin-4-yl-2,3-diphenyl-3H-imidazole-4-carboxylic acid methyl ester 
• 114171-32-3 2,2-Dimethyl-1-(2-morpholin-4-yl-4-phenyl-thiazol-5-yl)-propan-1-one 
• 115969-24-9 (4-Methoxy-phenyl)-(2-morpholin-4-yl-4-phenyl-thiazol-5-yl)-methanone 
• 59225-81-9 bis-(2-morpholin-4-yl-4-phenyl-thiazol-5-yl)-methanone 
• 59225-75-1 4-(5-nitro-4-phenyl-thiazol-2-yl)-morpholine 
• 55040-84-1 biphenyl-4-yl-(2-morpholin-4-yl-4-phenyl-thiazol-5-yl)-methanone 

Relevant academic research and scientific papers

Synthesis of Functionally Substituted 1,3-Diaza-1,3-butadienes

Three methods for the synthesis of various stable 1,3-diaza-1,3-butadienes from easily available thiourea derivatives are reported.

N'-Substituted N-Acyl- and N-Imidoyl-thioureas: Preparation and Conversion of N',N'-Disubstituted Compounds into 2-(N,N-Disubstituted Amino)thiazol-5-yl Ketones

Known methods were developed to give convenient general procedures for preparing N-acyl-N'-mono- and -N',N'-disubstituted thioureas from acid chlorides, and related N-imidoyl thioureas from imidoyl chlorides.In the products from three acid chlorides and ammonium thiocyanate the acyl isothiocyanates did not appear to be accompained by the isomeric thiocyanates.Treatment of N-(anilino)benzylidene-N',N'-disubstituted thioures with chloroacetone in the presence of triethylamine leads to 5-acetyl-4-phenyl-2-(N,N-disubstituted amino)thiazoles.In contrast, the corresponding N-benzoyl thioureas form only small amounts of these compounds; the main products are the 5-benzoyl-4-methyl isomers, and this unexpected outcome requires a revision of the literature.It is thought that formation of the 5-benzoyl-4-methylthiazoles involves N-C(4) fission of a cyclic intermediate to give an open-chain intermediate in which nucleophilic attack can occur at either the acetyl or the benzoyl group.One of the latter intermediates was generated directly from 2-acetyl-2-bromoacetophenone and N-methyl-N-phenylthiourea, and found to give the 5-benzoyl-4-methyl- and 5-acetyl-4-phenyl-thiazoles as the major and minor products, respectively.

REAKTIONEN AN NICKEL(II)KOORDINIERTEN N-ACYLTHIOHARNSTOFFEN MIT SAEURECHLORIDEN: EIN EINFACHER ZUGANG FUER NEUE THIOHARNSTOFF-DERIVATE

The reaction of transition metal coordinated N,N-dialkylsubstituted N'-benzoyl thioureas with electrophilic agents differs from the reaction of the non-coordinated ligands.The nickel(II)chelates 1 form with organic acid chlorides RCOCl the N',N'-diacylate