5097-28-9

Upstream product

• 110-89-4 piperidine 
• 36896-61-4 2,4-dimethoxyphenyllead triacetate 
• 4801-58-5 N-hydroxypiperidine 
• 110210-11-2 1-(2,4-dinitrophenoxy)piperidine 
• 151-10-0 1,3-Dimethoxybenzene 

Relevant academic research and scientific papers

Synthesis of Arylamines via Aminium Radicals

Arylamines constitute the core structure of many therapeutic agents, agrochemicals, and organic materials. The development of methods for the efficient and selective construction of these structural motifs from simple building blocks is desirable but stil

Aryllead Triacetates: Regioselective Reagents for N-Arylation of Amines

Aryllead triacetates have been found to be regioselective reagents for the mono N-arylation of a range of aromatic, heterocyclic and aliphatic amines under mild and neutral conditions in a reaction catalysed by copper diacetate.The arylation of arylamines was unaffected by the steric hindrance of the arylamine but was dependent on the arylamine basicity.In addition, the position of oxidisable substituents on both the aryllead triacetate and the arylamine was found to be important due to a competing oxidation-reduction reaction.The arylation of heterocyclic amines proceeded in modest to good yields whilst aliphatic amines were arylated in poor to modest yields.The mechanism proposed for these reactions involves transfer of the aryl group onto copper forming a copper(III) intermediate which subsequently undergoes ligand coupling to give the N-arylated amine and the catalytic CuI species.

ARYLATION OF AMINES BY ARYLLEAD TRIACETATES USING COPPER CATALYSIS.

The selective monoarylation of aliphatic, heterocyclic and aromatic amines has been performed with a variety of aryllead triacetates 1-4 under copper diacetate catalysis.