50978-40-0

Basic information

• Product Name: 4-PyridinaMine, 3,5-dichloro-2,6-diMethyl-
• Synonyms: 4-PyridinaMine, 3,5-dichloro-2,6-diMethyl-;3,5-Dichloro-2,6-dimethylpyridin-4-amine;3,5-dichloro-2,6-dimethyl-4-Pyridinamine
• CAS NO: 50978-40-0
• Molecular Formula: C7H8Cl2N2
• Molecular Weight: 191.05782
• Mol File: 50978-40-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-PyridinaMine, 3,5-dichloro-2,6-diMethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PyridinaMine, 3,5-dichloro-2,6-diMethyl-(50978-40-0)
• EPA Substance Registry System: 4-PyridinaMine, 3,5-dichloro-2,6-diMethyl-(50978-40-0)

Safety Data

• Hazardous Substances Data: 50978-40-0(Hazardous Substances Data)

Usage

Uses

3,5-Dichloro-2,6-dimethylpyridin-4-amine is an impurity of Clopidol (C587285) which is an antibiotic used in veterinary medicine as a coccidiostat in poultry. Showed low order of acute and chronic toxicity in animals.

Upstream product

• 28597-08-2 3,4,5-Trichloro-2,6-dimethylpyridine 
• 3512-80-9 4-amino-2,6-lutidine 
• 108-48-5 2,6-dimethylpyridine 
• 1073-23-0 2,6-lutidine N-oxide 

Relevant articles and documents

Preparation and purification method of toxic impurity DCAL of clopidol

The invention relates to a preparation and purification method of toxic impurity DCAL of clopidol and belongs to the technical field of preparation of standard medicine products. The preparation and purification method comprises the following steps: firstly carrying out chlorination reaction, i.e., dissolving a solvent and 2,6-dimethyl-4-aminopyridine; then slowly adding a chlorinating agent to carry out chlorination; after reaction is finished, carrying out neutralization and water washing, concentration and crystallization, filtering or direct neutralization and filtering on reaction liquidto obtain a crude DCAL product; purifying the crude DCAL product, adding a mixed solvent of ethanol and ethyl acetate into the crude DCAL product, stirring for dissolving, dripping petroleum ether toprecipitate solids, filtering, carrying out concentration, cooling and precipitation on filtrate, then filtering, and drying solids to obtain a pure DCAL product. The preparation and purification method has the beneficial effects that the reaction temperature is low, the reaction time is short, the side products in reaction are fewer, and the product is easily purified, so that convenience is brought for preparing impurity reference products of the veterinary-drug clopidol.