50983-76-1Relevant academic research and scientific papers
METHOD FOR MANUFACTURING RADIOACTIVE HALOGEN LABELED COMPOUND
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Paragraph 0031-0033, (2016/12/22)
PROBLEM TO BE SOLVED: To provide means for efficiently manufacturing a radioactive halogen labeled compound. SOLUTION: There is provided a method for manufacturing a radioactive halogen labeled compound represented by the formula: Sub-X, where Sub represents a substrate and X represents a radioactive halogen atom, and including (1) a process of reacting a high molecular compound containing a substrate and a radioactive halogenated ion under a condition where a phase transfer catalyst exists, (2) a process of binding a byproduct represented by a formula: Sub-OH, where Sub represents a substrate, isolating from the high molecular compound and a compound having an isocyanate group, (3) a process of removing a byproduct bound with the compound having the isocyanate group, and (4) a process of obtaining the radioactive halogen labeled compound from a reaction product of the high molecular compound and the radioactive halogenated ion. COPYRIGHT: (C)2015,JPOandINPIT
Cyclization of gold acetylides: Synthesis of vinyl sulfonates via gold vinylidene complexes
Bucher, Janina,Wurm, Thomas,Nalivela, Kumara Swamy,Rudolph, Matthias,Rominger, Frank,Hashmi, A. Stephen K.
supporting information, p. 3854 - 3858 (2014/05/06)
Differently substituted terminal alkynes that bear sulfonate leaving groups at an appropriate distance were converted in the presence of a propynyl gold(I) precatalyst. After initial formation of a gold acetylide, a cyclization takes place at the β-carbon atom of this species. Mechanistic studies support a mechanism that is related to that of dual gold-catalyzed reactions, but for the new substrates, only one gold atom is needed for substrate activation. After formation of a gold vinylidene complex, which forms a tight contact ion pair with the sulfonate leaving group, recombination of the two parts delivers vinyl sulfonates, which are valuable targets that can serve as precursors for cross-coupling reactions, for example. Gold vinylidene intermediates are generated by the cyclization of gold acetylides that carry a sulfonate leaving group. This result demonstrates for the first time that the formation of these species is not restricted to a dual activation mode. The cyclization products obtained herein contain a vinyl sulfonate moiety, which makes them useful building blocks for cross-coupling reactions.
Gold-catalyzed regioselective oxidation ofterminal allenes: Formation of α-methanesulfonyloxy methyl ketones
Luo, Yingdong,Zhang, Guozhu,Hwang, Erik S.,Wilcoxon, Thomas A.,Zhang, Liming
supporting information; experimental part, p. 596 - 600 (2011/06/26)
Synthetically useful α-methanesulfonyloxy methyl ketones are readily prepared in one-step from terminal allenes in fair to good yields. The chemistry relies on a gold-catalyzed intermolecular oxidation of the 1,2-diene unit using 3,5-dichloropyridine N-ox
