51-49-0 Usage
Chemical Properties
beige to light grey powder
Definition
ChEBI: The D-enantiomer of thyroxine.
Biological Functions
Dextrothyroxine, the synthetic D-(+)-stereoisomer isomer of L-(–)-T4, was introduced in hypocholesteremichypolipidemic therapy with the premise that it would be void of calorigenic effects. The possibility of trace
contamination with and metabolic conversion to T4 and congeners has restricted its use, however,
especially in patients with coronary heart disease.
Mechanism of action
Dextrothyroxine speeds up the decomposition of cholesterol and lipoproteins, thus activating
catabolism of cholesterol in the liver, which results in cholesterol being more intensively
transformed into bile salts. It lowers the level of low-density lipoproteins in the
plasma and very low-density lipoproteins in fatty tissue. It is recommended for treating
hyperlipoproteinemia.
Purification Methods
Recrystallise D-thyroxine from H2O (needles) or from an ammonical solution by dilution with H2O, MeOH or Me2CO. It has also been purified by dissolving ~6.5 g in a mixture of MeOH (200mL) and 2N HCl (20mL), adding charcoal, filtering then adding NaOAc solution to pH 6. On standing the thyroxine separates, it is filtered off, washed with MeOH then Me2CO and dried in vacuo. N-Formyl-D-thyroxine has m 210o and [] 21 -26.9o (c 5, EtOH). (±)-Thyroxine has m 256o and is purified in the same way. [Nahm & Siedel Chem Ber 96 1 1963, Salter Biochem J 24 471 1930, Beilstein 14 I 671, 14 II 384, 14 III 1566, 14 IV 2374.]
Check Digit Verification of cas no
The CAS Registry Mumber 51-49-0 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 1 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 51-49:
(4*5)+(3*1)+(2*4)+(1*9)=40
40 % 10 = 0
So 51-49-0 is a valid CAS Registry Number.
InChI:InChI=1/C16H13I4NO4/c1-7(16(23)24)21-6-8-2-12(19)15(13(20)3-8)25-9-4-10(17)14(22)11(18)5-9/h2-5,7,21-22H,6H2,1H3,(H,23,24)/t7-/m1/s1
51-49-0Relevant articles and documents
COMPOSITIONS AND METHODS FOR CYCLOFRUCTANS AS SEPARATION AGENTS
-
Page/Page column 45-49; 61, (2010/12/31)
The present invention relates to derivatized cyclofructan compounds, compositions comprising derivatized cyclofructan compounds, and methods of using compositions comprising derivatized cyclofructan compounds for chromatographic separations of chemical species, including enantiomers. Said compositions may comprise a solid support and/or polymers comprising derivatized cyclofructan compounds.
