510-38-3

Usage

Uses

Used in Pharmaceutical Industry:
(4R,4aS,6aS,7R,7aS,12aR,12bS)-7-methyl-3-methylidenedecahydro-2H,5H-2,4a-ethano-7,12a-propanobenzo[h][1,3]oxazolo[3,2-b]isoquinolin-4(12H)-ol is used as a potential pharmaceutical candidate for [application reason] due to its complex structure and the presence of both alcohol and ketone functional groups, which may contribute to its pharmacological or biological activities.
Used in Chemical Research:
In the field of chemical research, (4R,4aS,6aS,7R,7aS,12aR,12bS)-7-methyl-3-methylidenedecahydro-2H,5H-2,4a-ethano-7,12a-propanobenzo[h][1,3]oxazolo[3,2-b]isoquinolin-4(12H)-ol serves as a subject of study for understanding its specific applications and effects. Its unique molecular structure and the presence of multiple chiral centers make it an interesting compound for further analysis and potential development in various scientific and industrial applications.

Upstream product

• 466-43-3 atisine 
• 100428-75-9 Dihydroatisine 
• 60-29-7 diethyl ether 
• 100428-75-9 dihydroatisine 
• 7732-18-5 water 
• 1054-74-6 15-acetylatisine 

Relevant academic research and scientific papers

Conformational Analysis of the Oxazolidine and Tetrahydro-1,3-oxazine Ring of C20-Diterpenoid Alkaloid Derivatives

Chemical and spectral data about the behavior of the oxazolidine ring of atisine and veatchine in hydrogen-bonding and non-hydrogen-bonding solvents are presented.The steric effect of the C(16) methyl group on closure of the normal- and iso-type oxazolidine ring in various derivatives of atisine, veatchine, cuauchichicine, and garryfoline has been studied by 13C NMR spectroscopy.The normal-type oxazolidine ring of veatchine-related derivatives closes from one side of the trigonal C(20) carbon to give a single C(20) epimer when the C(16) methyl group is in a β configuration.By contrast, the presence of the C(16) methyl group in an α configuration affords both C(20) epimers on ring closure.The iso-type oxazolidine ring closes from both sides of the trigonal C(19) carbon to give both epimers regardless of the conformation of the C(16) methyl group.Treatment of various imine derivatives with glycidol afforded the favored six-membered tetrahydro-1,3-oxazine derivatives exclusively, instead of the possible five-membered oxazolidine-ring-containing derivatives.The structure of one of the isomers of 22-hydroxyhomoveatchine acetate (42) was confirmed by a single-crystal X-ray analysis.Modes of formation and stereochemistry at C(20) of the oxazolidine and tetrahydro-1,3-oxazine derivatives are discussed.

Construction of "normal"- and "iso-type" oxazolidine rings in C20-diterpenoid alkaloids: Oxidative cyclization with potassium ferricyanide

An efficient and simple method using alkaline ferricyanide for converting the NCH2CH2OH group-containing alkaloid derivatives into their "normal"- and "iso-type"-oxazolidine ring-containing alkaloids has been developed. This is the first one-step oxidation method which affords both types of oxazolidine rings simultaneously.

FORMATION OF THE OXAZOLIDINE RING IN C20-DITERPENOID ALKALOIDS BY OXIDATIVE CYCLIZATION WITH SILVER OXIDE

Treatment of the N-CH2-CH2OH group containing alkaloids with silver oxide in alcohol affords the "iso-type" oxazolidine ring-containing alkaloids in yield 72 to 90percent via oxidative cyclization.This method affords higher yields than earlier reported methods for this type transformation.